Genetics- and immune-related factors in the pathogenesis of lymphoplasmacytic lymphoma/ Waldenström's macroglobulinemia

Sigurdur Kristinsson, Jill Koshiol, Lynn Goldin, Magnus Björkholm, Ingemar Turesson, Gloria Gridley, Mary McMaster, Ola Landgren

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

There are emerging data to support a role for genetic and immune-related factors in the pathogenesis of lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia. In this article, we review our recently published, large, population-based studies using data from Sweden and from United States veterans and propose mechanisms and pathways underlying our observations. We also discuss future directions for new studies designed to increase our current knowledge and to define underlying biologic mechanisms of our findings. Finally, based on novel insights on this topic, we discuss clinical implications and provide perspective on the relevance of these data for patient counseling and clinical follow-up.

Original languageEnglish (US)
Pages (from-to)23-26
Number of pages4
JournalClinical Lymphoma and Myeloma
Volume9
Issue number1
DOIs
StatePublished - 2009
Externally publishedYes

Keywords

  • Autoimmune disease
  • Familial aggregation
  • Hepatitis C virus
  • Lymphoproliferative malignancy
  • Rheumatoid arthritis
  • Susceptibility
  • Waldenström

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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