Abstract
Age-related macular degeneration is a complex disease, with both genetic and environmental risk factors interacting in unknown ways. Currently, 52 gene variants within 34 loci have been significantly associated with age-related macular degeneration. Two well-studied major genes are complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2). There exist several commercially available tests that are proposed to stratify patients into high-risk and low-risk groups, as well as predict response to nutritional supplementation. However, at present, the bulk of the available peer-reviewed evidence suggests that genetic testing is more useful as a research tool than for clinical management of patients.
Original language | English (US) |
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Pages (from-to) | 1229-1235 |
Number of pages | 7 |
Journal | Clinical Ophthalmology |
Volume | 10 |
DOIs | |
State | Published - Jul 4 2016 |
Keywords
- ARMS2
- Age-related macular degeneration
- Age-related maculopathy susceptibility 2
- CFH
- Complement factor H
- Pharmacogenetics
- Vascular endothelial growth factor
ASJC Scopus subject areas
- Ophthalmology