Abstract
Age-related macular degeneration is a complex disease, with both genetic and environmental risk factors interacting in unknown ways. Currently, 52 gene variants within 34 loci have been significantly associated with age-related macular degeneration. Two well-studied major genes are complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2). There exist several commercially available tests that are proposed to stratify patients into high-risk and low-risk groups, as well as predict response to nutritional supplementation. However, at present, the bulk of the available peer-reviewed evidence suggests that genetic testing is more useful as a research tool than for clinical management of patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1229-1235 |
| Number of pages | 7 |
| Journal | Clinical Ophthalmology |
| Volume | 10 |
| DOIs | |
| State | Published - Jul 4 2016 |
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Keywords
- Age-related macular degeneration
- Age-related maculopathy susceptibility 2
- ARMS2
- CFH
- Complement factor H
- Pharmacogenetics
- Vascular endothelial growth factor
ASJC Scopus subject areas
- Ophthalmology
Cite this
Genetics and age-related macular degeneration : A practical review for the clinician. / Schwartz, Stephen; Hampton, Blake M.; Kovach, Jaclyn; Brantley, Milam A.
In: Clinical Ophthalmology, Vol. 10, 04.07.2016, p. 1229-1235.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Genetics and age-related macular degeneration
T2 - A practical review for the clinician
AU - Schwartz, Stephen
AU - Hampton, Blake M.
AU - Kovach, Jaclyn
AU - Brantley, Milam A.
PY - 2016/7/4
Y1 - 2016/7/4
N2 - Age-related macular degeneration is a complex disease, with both genetic and environmental risk factors interacting in unknown ways. Currently, 52 gene variants within 34 loci have been significantly associated with age-related macular degeneration. Two well-studied major genes are complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2). There exist several commercially available tests that are proposed to stratify patients into high-risk and low-risk groups, as well as predict response to nutritional supplementation. However, at present, the bulk of the available peer-reviewed evidence suggests that genetic testing is more useful as a research tool than for clinical management of patients.
AB - Age-related macular degeneration is a complex disease, with both genetic and environmental risk factors interacting in unknown ways. Currently, 52 gene variants within 34 loci have been significantly associated with age-related macular degeneration. Two well-studied major genes are complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2). There exist several commercially available tests that are proposed to stratify patients into high-risk and low-risk groups, as well as predict response to nutritional supplementation. However, at present, the bulk of the available peer-reviewed evidence suggests that genetic testing is more useful as a research tool than for clinical management of patients.
KW - Age-related macular degeneration
KW - Age-related maculopathy susceptibility 2
KW - ARMS2
KW - CFH
KW - Complement factor H
KW - Pharmacogenetics
KW - Vascular endothelial growth factor
UR - http://www.scopus.com/inward/record.url?scp=84980496703&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84980496703&partnerID=8YFLogxK
U2 - 10.2147/OPTH.S109723
DO - 10.2147/OPTH.S109723
M3 - Review article
AN - SCOPUS:84980496703
VL - 10
SP - 1229
EP - 1235
JO - Clinical Ophthalmology
JF - Clinical Ophthalmology
SN - 1177-5467
ER -