Genetic variation near IRS1 is associated with adiposity and a favorable metabolic profile in U.S. Hispanics/Latinos

Qibin Qi, Stephanie M. Gogarten, Leslie S. Emery, Tin Louie, Adrienne Stilp, Jianwen Cai, Neil Schneiderman, M. Larissa Avilés-Santa, Robert C. Kaplan, Kari E. North, Cathy C. Laurie, Ruth J F Loos, Carmen R. Isasi

Research output: Contribution to journalArticle

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Abstract

Objective: Associations of IRS1 genetic variation with adiposity and metabolic profile in U.S. Hispanic/Latino individuals of diverse backgrounds were examined. Methods: Previously genome-wide association study-identified IRS1 variants (rs2943650, rs2972146, rs2943641, and rs2943634) as related to body fat percentage (BF%) and multiple metabolic traits were tested among up to 12,730 adults (5,232 men; 7,515 women) from the Hispanic Community Health Study/Study of Latinos. Results: The C-allele (frequency = 26%) of rs2943650 was significantly associated with higher BF% overall (β = 0.34 ± 0.11% per allele; P = 0.002) and in women (β = 0.41 ± 0.14% per C-allele; P = 0.003), but not in men (β = 0.28 ± 0.18% per C-allele; P = 0.11), though there was no significant sex difference. Using the inverse normal-transformed data to compare effect sizes, it was found that the association with BF% was stronger in Hispanic/Latino women than that previously reported in European women (β = 0.054 ± 0.018SD vs. β = 0.008 ± 0.011SD per C-allele; P = 0.03). The BF%-increasing allele of rs2943650 was significantly associated with lower levels of fasting insulin, homeostatic model assessment of insulin resistance, hemoglobin A1c, and triglycerides and higher high-density lipoprotein cholesterol (P < 0.05). Conclusions: This study confirmed and extended previous findings of IRS1 variation associated with increased adiposity but a favorable metabolic profile in U.S. Hispanics/Latinos, with a relatively stronger genetic effect on BF% in Hispanic/Latino women compared with European women.

Original languageEnglish (US)
Pages (from-to)2407-2413
Number of pages7
JournalObesity
Volume24
Issue number11
DOIs
StatePublished - Nov 1 2016

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Metabolome
Adiposity
Hispanic Americans
Adipose Tissue
Alleles
Genome-Wide Association Study
Gene Frequency
Sex Characteristics
HDL Cholesterol
Insulin Resistance
Fasting
Hemoglobins
Triglycerides
Insulin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Qi, Q., Gogarten, S. M., Emery, L. S., Louie, T., Stilp, A., Cai, J., ... Isasi, C. R. (2016). Genetic variation near IRS1 is associated with adiposity and a favorable metabolic profile in U.S. Hispanics/Latinos. Obesity, 24(11), 2407-2413. https://doi.org/10.1002/oby.21624

Genetic variation near IRS1 is associated with adiposity and a favorable metabolic profile in U.S. Hispanics/Latinos. / Qi, Qibin; Gogarten, Stephanie M.; Emery, Leslie S.; Louie, Tin; Stilp, Adrienne; Cai, Jianwen; Schneiderman, Neil; Avilés-Santa, M. Larissa; Kaplan, Robert C.; North, Kari E.; Laurie, Cathy C.; Loos, Ruth J F; Isasi, Carmen R.

In: Obesity, Vol. 24, No. 11, 01.11.2016, p. 2407-2413.

Research output: Contribution to journalArticle

Qi, Q, Gogarten, SM, Emery, LS, Louie, T, Stilp, A, Cai, J, Schneiderman, N, Avilés-Santa, ML, Kaplan, RC, North, KE, Laurie, CC, Loos, RJF & Isasi, CR 2016, 'Genetic variation near IRS1 is associated with adiposity and a favorable metabolic profile in U.S. Hispanics/Latinos', Obesity, vol. 24, no. 11, pp. 2407-2413. https://doi.org/10.1002/oby.21624
Qi, Qibin ; Gogarten, Stephanie M. ; Emery, Leslie S. ; Louie, Tin ; Stilp, Adrienne ; Cai, Jianwen ; Schneiderman, Neil ; Avilés-Santa, M. Larissa ; Kaplan, Robert C. ; North, Kari E. ; Laurie, Cathy C. ; Loos, Ruth J F ; Isasi, Carmen R. / Genetic variation near IRS1 is associated with adiposity and a favorable metabolic profile in U.S. Hispanics/Latinos. In: Obesity. 2016 ; Vol. 24, No. 11. pp. 2407-2413.
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abstract = "Objective: Associations of IRS1 genetic variation with adiposity and metabolic profile in U.S. Hispanic/Latino individuals of diverse backgrounds were examined. Methods: Previously genome-wide association study-identified IRS1 variants (rs2943650, rs2972146, rs2943641, and rs2943634) as related to body fat percentage (BF{\%}) and multiple metabolic traits were tested among up to 12,730 adults (5,232 men; 7,515 women) from the Hispanic Community Health Study/Study of Latinos. Results: The C-allele (frequency = 26{\%}) of rs2943650 was significantly associated with higher BF{\%} overall (β = 0.34 ± 0.11{\%} per allele; P = 0.002) and in women (β = 0.41 ± 0.14{\%} per C-allele; P = 0.003), but not in men (β = 0.28 ± 0.18{\%} per C-allele; P = 0.11), though there was no significant sex difference. Using the inverse normal-transformed data to compare effect sizes, it was found that the association with BF{\%} was stronger in Hispanic/Latino women than that previously reported in European women (β = 0.054 ± 0.018SD vs. β = 0.008 ± 0.011SD per C-allele; P = 0.03). The BF{\%}-increasing allele of rs2943650 was significantly associated with lower levels of fasting insulin, homeostatic model assessment of insulin resistance, hemoglobin A1c, and triglycerides and higher high-density lipoprotein cholesterol (P < 0.05). Conclusions: This study confirmed and extended previous findings of IRS1 variation associated with increased adiposity but a favorable metabolic profile in U.S. Hispanics/Latinos, with a relatively stronger genetic effect on BF{\%} in Hispanic/Latino women compared with European women.",
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T1 - Genetic variation near IRS1 is associated with adiposity and a favorable metabolic profile in U.S. Hispanics/Latinos

AU - Qi, Qibin

AU - Gogarten, Stephanie M.

AU - Emery, Leslie S.

AU - Louie, Tin

AU - Stilp, Adrienne

AU - Cai, Jianwen

AU - Schneiderman, Neil

AU - Avilés-Santa, M. Larissa

AU - Kaplan, Robert C.

AU - North, Kari E.

AU - Laurie, Cathy C.

AU - Loos, Ruth J F

AU - Isasi, Carmen R.

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N2 - Objective: Associations of IRS1 genetic variation with adiposity and metabolic profile in U.S. Hispanic/Latino individuals of diverse backgrounds were examined. Methods: Previously genome-wide association study-identified IRS1 variants (rs2943650, rs2972146, rs2943641, and rs2943634) as related to body fat percentage (BF%) and multiple metabolic traits were tested among up to 12,730 adults (5,232 men; 7,515 women) from the Hispanic Community Health Study/Study of Latinos. Results: The C-allele (frequency = 26%) of rs2943650 was significantly associated with higher BF% overall (β = 0.34 ± 0.11% per allele; P = 0.002) and in women (β = 0.41 ± 0.14% per C-allele; P = 0.003), but not in men (β = 0.28 ± 0.18% per C-allele; P = 0.11), though there was no significant sex difference. Using the inverse normal-transformed data to compare effect sizes, it was found that the association with BF% was stronger in Hispanic/Latino women than that previously reported in European women (β = 0.054 ± 0.018SD vs. β = 0.008 ± 0.011SD per C-allele; P = 0.03). The BF%-increasing allele of rs2943650 was significantly associated with lower levels of fasting insulin, homeostatic model assessment of insulin resistance, hemoglobin A1c, and triglycerides and higher high-density lipoprotein cholesterol (P < 0.05). Conclusions: This study confirmed and extended previous findings of IRS1 variation associated with increased adiposity but a favorable metabolic profile in U.S. Hispanics/Latinos, with a relatively stronger genetic effect on BF% in Hispanic/Latino women compared with European women.

AB - Objective: Associations of IRS1 genetic variation with adiposity and metabolic profile in U.S. Hispanic/Latino individuals of diverse backgrounds were examined. Methods: Previously genome-wide association study-identified IRS1 variants (rs2943650, rs2972146, rs2943641, and rs2943634) as related to body fat percentage (BF%) and multiple metabolic traits were tested among up to 12,730 adults (5,232 men; 7,515 women) from the Hispanic Community Health Study/Study of Latinos. Results: The C-allele (frequency = 26%) of rs2943650 was significantly associated with higher BF% overall (β = 0.34 ± 0.11% per allele; P = 0.002) and in women (β = 0.41 ± 0.14% per C-allele; P = 0.003), but not in men (β = 0.28 ± 0.18% per C-allele; P = 0.11), though there was no significant sex difference. Using the inverse normal-transformed data to compare effect sizes, it was found that the association with BF% was stronger in Hispanic/Latino women than that previously reported in European women (β = 0.054 ± 0.018SD vs. β = 0.008 ± 0.011SD per C-allele; P = 0.03). The BF%-increasing allele of rs2943650 was significantly associated with lower levels of fasting insulin, homeostatic model assessment of insulin resistance, hemoglobin A1c, and triglycerides and higher high-density lipoprotein cholesterol (P < 0.05). Conclusions: This study confirmed and extended previous findings of IRS1 variation associated with increased adiposity but a favorable metabolic profile in U.S. Hispanics/Latinos, with a relatively stronger genetic effect on BF% in Hispanic/Latino women compared with European women.

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