Genetic variance of blood pressure levels in infant twins

Robert S. Levine, Charles H. Hennekens, Anne Perry, Janet Cassady, Henry Gelband, Mary Jane Jesse

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

A cohort of 166 twin pairs (67 monozygotic and 99 dizygotic) born at the Jackson Memorial Hospital/University of Miami Medical Center between July 1, 1976 and December 31, 1980, was followed from birth to one year of age in order to estimate the genetic variance of blood pressure during the first year of life. The sex-adjusted summary estimate of heritability for systolic blood pressure during all of infancy was 0.22 (p <0.001), but statistically significant genetic variance was not found for diastolic blood pressure. When using blood pressures from six to 12 months of age, adjusted for infant sex, heritability was estimated as 0.33 (p <0.001) for systolic blood pressure and 0.24 (p = 0.04) for diastolic blood pressure; adjustment for body weight reduced these estimates to 0.27 (p <0.001) and 0.17 (p = 0.13), respectively.

Original languageEnglish (US)
Pages (from-to)759-764
Number of pages6
JournalAmerican journal of epidemiology
Volume116
Issue number5
DOIs
StatePublished - Nov 1982

Keywords

  • Blood pressure
  • Genetics
  • Infant

ASJC Scopus subject areas

  • Epidemiology

Fingerprint Dive into the research topics of 'Genetic variance of blood pressure levels in infant twins'. Together they form a unique fingerprint.

  • Cite this

    Levine, R. S., Hennekens, C. H., Perry, A., Cassady, J., Gelband, H., & Jesse, M. J. (1982). Genetic variance of blood pressure levels in infant twins. American journal of epidemiology, 116(5), 759-764. https://doi.org/10.1093/oxfordjournals.aje.a113465