@article{6ee603f6972a40e7a0f0ffe5d589d1a8,
title = "Genetic variance of blood pressure levels in infant twins",
abstract = "A cohort of 166 twin pairs (67 monozygotic and 99 dizygotic) born at the Jackson Memorial Hospital/University of Miami Medical Center between July 1, 1976 and December 31, 1980, was followed from birth to one year of age in order to estimate the genetic variance of blood pressure during the first year of life. The sex-adjusted summary estimate of heritability for systolic blood pressure during all of infancy was 0.22 (p <0.001), but statistically significant genetic variance was not found for diastolic blood pressure. When using blood pressures from six to 12 months of age, adjusted for infant sex, heritability was estimated as 0.33 (p <0.001) for systolic blood pressure and 0.24 (p = 0.04) for diastolic blood pressure; adjustment for body weight reduced these estimates to 0.27 (p <0.001) and 0.17 (p = 0.13), respectively.",
keywords = "Blood pressure, Genetics, Infant",
author = "Levine, {Robert S.} and Hennekens, {Charles H.} and Anne Perry and Janet Cassady and Henry Gelband and Jesse, {Mary Jane}",
note = "Funding Information: Received for publication January 18, 1982, and in final form June 14, 1982. Abbreviations1 : DZ, dizygotic; MZ, monozygotic. Departments of Epidemiology and Public Health, and Pediatrics, University of Miami School of Medicine. (Reprint requests to Dr. Levine, Department of Epidemiology and Public Health, University of Miami School of Medicine, P.O. Box 0160691 , Miami, FL 33101.) Channing Laboratory, Departments of Medicine and Preventive and Social Medicine, Harvard Medical School and Peter Bent Brigham Hospital, Boston, MA. 3Department of Pediatrics, University of Miami School of Medicine. This work was supported by a research grant (HL 19930) from the National Heart, Lung and Blood Institute. Dr. Hennekens is a recipient of a Research Career Development Award (HL 00286) from the National Heart, Lung and Blood Institute. Computer programs used in the analyses of these data were provided in part by the Indiana University Human Genetics Center (PHS P50 GM 21054).",
year = "1982",
month = nov,
doi = "10.1093/oxfordjournals.aje.a113465",
language = "English (US)",
volume = "116",
pages = "759--764",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "5",
}