Genetic testing for early detection of individuals at risk of coronary heart disease and monitoring response to therapy: Challenges and promises

H. Robert Superko, Robert Roberts, Arthur Agatston, Stephen Frohwein, Jason S. Reingold, Thomas J. White, John J. Sninsky, Basil Margolis, Kathryn M. Momary, Brenda C. Garrett, Spencer B. King

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Coronary heart disease (CHD) often presents suddenly with little warning. Traditional risk factors are inadequate to identify the asymptomatic high-risk individuals. Early identification of patients with subclinical coronary artery disease using noninvasive imaging modalities would allow the early adoption of aggressive preventative interventions. Currently, it is impractical to screen the entire population with noninvasive coronary imaging tools. The use of relatively simple and inexpensive geneticmarkers of increased CHD risk can identify a population subgroup in which benefit of atherosclerotic imaging modalities would be increased despite nominal cost and radiation exposure. Additionally, genetic markers are fixed and need only be measured once in a patient's lifetime, can help guide therapy selection, and may be of utility in family counseling.

Original languageEnglish (US)
Pages (from-to)396-404
Number of pages9
JournalCurrent atherosclerosis reports
Volume13
Issue number5
DOIs
StatePublished - Oct 2011

Keywords

  • Coronary heart disease
  • Genetic
  • Imaging
  • Risk factor
  • Screening

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Superko, H. R., Roberts, R., Agatston, A., Frohwein, S., Reingold, J. S., White, T. J., Sninsky, J. J., Margolis, B., Momary, K. M., Garrett, B. C., & King, S. B. (2011). Genetic testing for early detection of individuals at risk of coronary heart disease and monitoring response to therapy: Challenges and promises. Current atherosclerosis reports, 13(5), 396-404. https://doi.org/10.1007/s11883-011-0198-8