@article{64a1e54b3de34b8bac2d5c71e6f513d0,
title = "Genetic testing for early detection of individuals at risk of coronary heart disease and monitoring response to therapy: Challenges and promises",
abstract = "Coronary heart disease (CHD) often presents suddenly with little warning. Traditional risk factors are inadequate to identify the asymptomatic high-risk individuals. Early identification of patients with subclinical coronary artery disease using noninvasive imaging modalities would allow the early adoption of aggressive preventative interventions. Currently, it is impractical to screen the entire population with noninvasive coronary imaging tools. The use of relatively simple and inexpensive geneticmarkers of increased CHD risk can identify a population subgroup in which benefit of atherosclerotic imaging modalities would be increased despite nominal cost and radiation exposure. Additionally, genetic markers are fixed and need only be measured once in a patient's lifetime, can help guide therapy selection, and may be of utility in family counseling.",
keywords = "Coronary heart disease, Genetic, Imaging, Risk factor, Screening",
author = "Superko, {H. Robert} and Robert Roberts and Arthur Agatston and Stephen Frohwein and Reingold, {Jason S.} and White, {Thomas J.} and Sninsky, {John J.} and Basil Margolis and Momary, {Kathryn M.} and Garrett, {Brenda C.} and King, {Spencer B.}",
note = "Funding Information: Disclosure H.R. Superko is employed by Celera Corporation, and is a board member of CGHDI, a 501C3 nonprofit. R. Roberts is a consultant for Celera Scientific Advisory Committee. A. Agatston has nothing to disclose. S. Frohwein has nothing to disclose. J.S. Reingold has nothing to disclose. T.J. White is employed by Celera Corporation and owns stock/stock options in the company. J.J. Sninsky is employed by Celera Corporation and owns stock/stock options in the company. B. Margolis is a consultant for Celera Corporation and has received honoraria for speaking from the Berkeley Heart Lab. K.M. Momary has received grants from Pfizer and honoraria from Sanofi-Aventis and Novartis. B.C. Garrett is a lay board member of the SHAPE Society but receives no compensation for the position and is also married to H.R. Superko. S.B. King has received a grant from FEMA, is a consultant for Celonova Biosciences, has received payment from the Network for Continuing Medical Education for development of educational presentations, and is on Data Safety Monitoring Boards for Merck & Co., Wyeth Pharmaceuticals, and nContact Surgical Open Access This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.",
year = "2011",
month = oct,
doi = "10.1007/s11883-011-0198-8",
language = "English (US)",
volume = "13",
pages = "396--404",
journal = "Current Atherosclerosis Reports",
issn = "1523-3804",
publisher = "Current Medicine Group",
number = "5",
}