Genetic susceptibility to atracurium-induced bronchoconstriction

Roy C Levitt, S. L. Ewart

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The goal of this study was to develop a murine model of atracurium- induced bronchoconstriction in which to evaluate the mechanism of action of this airway response. We evaluated nine inbred strains of mice for the development of atracurium-induced bronchoconstriction. The maximal difference in the magnitude of the airway response to atracurium noted between the highly responsive DBA/2 mice and the minimally responsive SJL mice was greater than 20-fold. This phenotype appears to reflect an intrinsic difference in the lungs of these animals because the extent of neuromuscular blockade was not significantly different in DBA/2 and SJL mice. Atracurium- induced airway hyperresponsiveness in DBA/2 mice was eliminated in a dose- dependent manner by pretreatment with atropine or pancuronium. These data are consistent with a postganglionic vagal efferent mechanism which produces a differential pulmonary response to this neuromuscular blocker. A genetic predisposition to atracurium-induced bronchoconstriction appears to exist in certain inbred strains of mice. Thus, a mouse model may be useful for mapping the gene(s) that control this trait and for suggesting responsible candidate genes. Our results suggest that the inbred laboratory mouse will be useful to study the mechanism by which atracurium produces bronchoconstriction.

Original languageEnglish
Pages (from-to)1537-1542
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume151
Issue number5
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Atracurium
Bronchoconstriction
Genetic Predisposition to Disease
Inbred DBA Mouse
Inbred Strains Mice
Neuromuscular Blocking Agents
Pancuronium
Lung
Neuromuscular Blockade
Chromosome Mapping
Atropine
Phenotype
Genes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Genetic susceptibility to atracurium-induced bronchoconstriction. / Levitt, Roy C; Ewart, S. L.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 151, No. 5, 01.01.1995, p. 1537-1542.

Research output: Contribution to journalArticle

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