Genetic susceptibility to Alzheimer disease

Margaret A. Pericak-Vance, Jonathan L. Haines

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

Alzheimer disease (AD) is the leading cause of dementia in the elderly. Less than a decade ago, it was questioned as to whether or not genes were even involved in anything but rare early onset AD. Since that time, using a variety of genetic epidemiological and molecular biological techniques, four loci have been identified that play a role in the genetic susceptibility of AD, AD presents as a prototype of the power of genetic techniques in defining the etiology of a complex disease.

Original languageEnglish (US)
Pages (from-to)504-508
Number of pages5
JournalTrends in Genetics
Volume11
Issue number12
DOIs
StatePublished - Dec 1995
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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