Genetic studies in Alzheimer's disease with an NACP/α-synuclein polymorphism

Yu Xia, H. A. De Rohan Suva, Barbara L. Rosi, Larry H. Yamaoka, Jacqueline B. Rimmler, Margaret A. Pericak-Vance, Allen D. Roses, Xiaohua Chen, Eliezer Masliah, Richard Deteresa, Akihiko Iwai, Mary Sundsmo, Ronald G. Thomas, C. Richard Hofstetter, Ethan Gregory, Lawrence A. Hansen, Robert Katzman, Leon J. Thai, Tsunao Saitoh

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

The non-Aβ component of Alzheimer's disease amyloid (NAC) is copurified with amyloid from the brain tissue of Alzheimer's disease victims and is immunohistochemically localized to amyloid fibrils. NAC is a hydrophobic peptide fragment from the NAC precursor protein (NACP/α-synuclein) that is localized to presynaptic terminals. We used a polymorphic dinucleotide repeat sequence in a genomic clone of NACP for genetic association and linkage studies. Screening of Alzheimer's disease families failed to establish linkage between NACP and Alzheimer's disease. Nevertheless, one of the NACP polymorphisms (NACP allele 2) was shown to have significant association with healthy elderly control individuals with apolipoprotein E risk. This may indicate a possible protective function of the allele.

Original languageEnglish (US)
Pages (from-to)207-215
Number of pages9
JournalAnnals of neurology
Volume40
Issue number2
DOIs
StatePublished - Aug 1996
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Xia, Y., De Rohan Suva, H. A., Rosi, B. L., Yamaoka, L. H., Rimmler, J. B., Pericak-Vance, M. A., Roses, A. D., Chen, X., Masliah, E., Deteresa, R., Iwai, A., Sundsmo, M., Thomas, R. G., Richard Hofstetter, C., Gregory, E., Hansen, L. A., Katzman, R., Thai, L. J., & Saitoh, T. (1996). Genetic studies in Alzheimer's disease with an NACP/α-synuclein polymorphism. Annals of neurology, 40(2), 207-215. https://doi.org/10.1002/ana.410400212