Genetic studies in Alzheimer's disease with an NACP/α-synuclein polymorphism

Yu Xia; H. A. De Rohan Suva; Barbara L. Rosi; Larry H. Yamaoka; Jacqueline B. Rimmler; Margaret A. Pericak-Vance; Allen D. Roses; Xiaohua Chen; Eliezer Masliah; Richard Deteresa; Akihiko Iwai; Mary Sundsmo; Ronald G. Thomas; C. Richard Hofstetter; Ethan Gregory; Lawrence A. Hansen; Robert Katzman; Leon J. Thai; Tsunao Saitoh

doi:10.1002/ana.410400212

Genetic studies in Alzheimer's disease with an NACP/α-synuclein polymorphism

Yu Xia, H. A. De Rohan Suva, Barbara L. Rosi, Larry H. Yamaoka, Jacqueline B. Rimmler, Margaret A. Pericak-Vance, Allen D. Roses, Xiaohua Chen, Eliezer Masliah, Richard Deteresa, Akihiko Iwai, Mary Sundsmo, Ronald G. Thomas, C. Richard Hofstetter, Ethan Gregory, Lawrence A. Hansen, Robert Katzman, Leon J. Thai, Tsunao Saitoh

Research output: Contribution to journal › Article

95 Scopus citations

Abstract

The non-Aβ component of Alzheimer's disease amyloid (NAC) is copurified with amyloid from the brain tissue of Alzheimer's disease victims and is immunohistochemically localized to amyloid fibrils. NAC is a hydrophobic peptide fragment from the NAC precursor protein (NACP/α-synuclein) that is localized to presynaptic terminals. We used a polymorphic dinucleotide repeat sequence in a genomic clone of NACP for genetic association and linkage studies. Screening of Alzheimer's disease families failed to establish linkage between NACP and Alzheimer's disease. Nevertheless, one of the NACP polymorphisms (NACP allele 2) was shown to have significant association with healthy elderly control individuals with apolipoprotein E risk. This may indicate a possible protective function of the allele.

Original language	English (US)
Pages (from-to)	207-215
Number of pages	9
Journal	Annals of neurology
Volume	40
Issue number	2
DOIs	https://doi.org/10.1002/ana.410400212
State	Published - Aug 1996
Externally published	Yes

ASJC Scopus subject areas

Neurology
Clinical Neurology

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Xia, Y., De Rohan Suva, H. A., Rosi, B. L., Yamaoka, L. H., Rimmler, J. B., Pericak-Vance, M. A., Roses, A. D., Chen, X., Masliah, E., Deteresa, R., Iwai, A., Sundsmo, M., Thomas, R. G., Richard Hofstetter, C., Gregory, E., Hansen, L. A., Katzman, R., Thai, L. J., & Saitoh, T. (1996). Genetic studies in Alzheimer's disease with an NACP/α-synuclein polymorphism. Annals of neurology, 40(2), 207-215. https://doi.org/10.1002/ana.410400212

Genetic studies in Alzheimer's disease with an NACP/α-synuclein polymorphism. / Xia, Yu; De Rohan Suva, H. A.; Rosi, Barbara L.; Yamaoka, Larry H.; Rimmler, Jacqueline B.; Pericak-Vance, Margaret A.; Roses, Allen D.; Chen, Xiaohua; Masliah, Eliezer; Deteresa, Richard; Iwai, Akihiko; Sundsmo, Mary; Thomas, Ronald G.; Richard Hofstetter, C.; Gregory, Ethan; Hansen, Lawrence A.; Katzman, Robert; Thai, Leon J.; Saitoh, Tsunao.

In: Annals of neurology, Vol. 40, No. 2, 08.1996, p. 207-215.

Research output: Contribution to journal › Article

Xia, Y, De Rohan Suva, HA, Rosi, BL, Yamaoka, LH, Rimmler, JB, Pericak-Vance, MA, Roses, AD, Chen, X, Masliah, E, Deteresa, R, Iwai, A, Sundsmo, M, Thomas, RG, Richard Hofstetter, C, Gregory, E, Hansen, LA, Katzman, R, Thai, LJ & Saitoh, T 1996, 'Genetic studies in Alzheimer's disease with an NACP/α-synuclein polymorphism', Annals of neurology, vol. 40, no. 2, pp. 207-215. https://doi.org/10.1002/ana.410400212

Xia, Yu ; De Rohan Suva, H. A. ; Rosi, Barbara L. ; Yamaoka, Larry H. ; Rimmler, Jacqueline B. ; Pericak-Vance, Margaret A. ; Roses, Allen D. ; Chen, Xiaohua ; Masliah, Eliezer ; Deteresa, Richard ; Iwai, Akihiko ; Sundsmo, Mary ; Thomas, Ronald G. ; Richard Hofstetter, C. ; Gregory, Ethan ; Hansen, Lawrence A. ; Katzman, Robert ; Thai, Leon J. ; Saitoh, Tsunao. / Genetic studies in Alzheimer's disease with an NACP/α-synuclein polymorphism. In: Annals of neurology. 1996 ; Vol. 40, No. 2. pp. 207-215.

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title = "Genetic studies in Alzheimer's disease with an NACP/α-synuclein polymorphism",

abstract = "The non-Aβ component of Alzheimer's disease amyloid (NAC) is copurified with amyloid from the brain tissue of Alzheimer's disease victims and is immunohistochemically localized to amyloid fibrils. NAC is a hydrophobic peptide fragment from the NAC precursor protein (NACP/α-synuclein) that is localized to presynaptic terminals. We used a polymorphic dinucleotide repeat sequence in a genomic clone of NACP for genetic association and linkage studies. Screening of Alzheimer's disease families failed to establish linkage between NACP and Alzheimer's disease. Nevertheless, one of the NACP polymorphisms (NACP allele 2) was shown to have significant association with healthy elderly control individuals with apolipoprotein E risk. This may indicate a possible protective function of the allele.",

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AU - De Rohan Suva, H. A.

AU - Rosi, Barbara L.

AU - Yamaoka, Larry H.

AU - Rimmler, Jacqueline B.

AU - Pericak-Vance, Margaret A.

AU - Roses, Allen D.

AU - Chen, Xiaohua

AU - Masliah, Eliezer

AU - Deteresa, Richard

AU - Iwai, Akihiko

AU - Sundsmo, Mary

AU - Thomas, Ronald G.

AU - Richard Hofstetter, C.

AU - Gregory, Ethan

AU - Hansen, Lawrence A.

AU - Katzman, Robert

AU - Thai, Leon J.

AU - Saitoh, Tsunao

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AB - The non-Aβ component of Alzheimer's disease amyloid (NAC) is copurified with amyloid from the brain tissue of Alzheimer's disease victims and is immunohistochemically localized to amyloid fibrils. NAC is a hydrophobic peptide fragment from the NAC precursor protein (NACP/α-synuclein) that is localized to presynaptic terminals. We used a polymorphic dinucleotide repeat sequence in a genomic clone of NACP for genetic association and linkage studies. Screening of Alzheimer's disease families failed to establish linkage between NACP and Alzheimer's disease. Nevertheless, one of the NACP polymorphisms (NACP allele 2) was shown to have significant association with healthy elderly control individuals with apolipoprotein E risk. This may indicate a possible protective function of the allele.

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