Abstract
The non-Aβ component of Alzheimer's disease amyloid (NAC) is copurified with amyloid from the brain tissue of Alzheimer's disease victims and is immunohistochemically localized to amyloid fibrils. NAC is a hydrophobic peptide fragment from the NAC precursor protein (NACP/α-synuclein) that is localized to presynaptic terminals. We used a polymorphic dinucleotide repeat sequence in a genomic clone of NACP for genetic association and linkage studies. Screening of Alzheimer's disease families failed to establish linkage between NACP and Alzheimer's disease. Nevertheless, one of the NACP polymorphisms (NACP allele 2) was shown to have significant association with healthy elderly control individuals with apolipoprotein E risk. This may indicate a possible protective function of the allele.
| Original language | English |
|---|---|
| Pages (from-to) | 207-215 |
| Number of pages | 9 |
| Journal | Annals of Neurology |
| Volume | 40 |
| Issue number | 2 |
| State | Published - Aug 1 1996 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Genetic studies in Alzheimer's disease with an NACP/α-synuclein polymorphism. / Xia, Yu; De Rohan Suva, H. A.; Rosi, Barbara L.; Yamaoka, Larry H.; Rimmler, Jacqueline B.; Pericak-Vance, Margaret A; Roses, Allen D.; Chen, Xiaohua; Masliah, Eliezer; Deteresa, Richard; Iwai, Akihiko; Sundsmo, Mary; Thomas, Ronald G.; Richard Hofstetter, C.; Gregory, Ethan; Hansen, Lawrence A.; Katzman, Robert; Thai, Leon J.; Saitoh, Tsunao.
In: Annals of Neurology, Vol. 40, No. 2, 01.08.1996, p. 207-215.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetic studies in Alzheimer's disease with an NACP/α-synuclein polymorphism
AU - Xia, Yu
AU - De Rohan Suva, H. A.
AU - Rosi, Barbara L.
AU - Yamaoka, Larry H.
AU - Rimmler, Jacqueline B.
AU - Pericak-Vance, Margaret A
AU - Roses, Allen D.
AU - Chen, Xiaohua
AU - Masliah, Eliezer
AU - Deteresa, Richard
AU - Iwai, Akihiko
AU - Sundsmo, Mary
AU - Thomas, Ronald G.
AU - Richard Hofstetter, C.
AU - Gregory, Ethan
AU - Hansen, Lawrence A.
AU - Katzman, Robert
AU - Thai, Leon J.
AU - Saitoh, Tsunao
PY - 1996/8/1
Y1 - 1996/8/1
N2 - The non-Aβ component of Alzheimer's disease amyloid (NAC) is copurified with amyloid from the brain tissue of Alzheimer's disease victims and is immunohistochemically localized to amyloid fibrils. NAC is a hydrophobic peptide fragment from the NAC precursor protein (NACP/α-synuclein) that is localized to presynaptic terminals. We used a polymorphic dinucleotide repeat sequence in a genomic clone of NACP for genetic association and linkage studies. Screening of Alzheimer's disease families failed to establish linkage between NACP and Alzheimer's disease. Nevertheless, one of the NACP polymorphisms (NACP allele 2) was shown to have significant association with healthy elderly control individuals with apolipoprotein E risk. This may indicate a possible protective function of the allele.
AB - The non-Aβ component of Alzheimer's disease amyloid (NAC) is copurified with amyloid from the brain tissue of Alzheimer's disease victims and is immunohistochemically localized to amyloid fibrils. NAC is a hydrophobic peptide fragment from the NAC precursor protein (NACP/α-synuclein) that is localized to presynaptic terminals. We used a polymorphic dinucleotide repeat sequence in a genomic clone of NACP for genetic association and linkage studies. Screening of Alzheimer's disease families failed to establish linkage between NACP and Alzheimer's disease. Nevertheless, one of the NACP polymorphisms (NACP allele 2) was shown to have significant association with healthy elderly control individuals with apolipoprotein E risk. This may indicate a possible protective function of the allele.
UR - http://www.scopus.com/inward/record.url?scp=9444298408&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=9444298408&partnerID=8YFLogxK
M3 - Article
C2 - 8773602
AN - SCOPUS:9444298408
VL - 40
SP - 207
EP - 215
JO - Annals of Neurology
JF - Annals of Neurology
SN - 0364-5134
IS - 2
ER -