Genetic risk factors for parkinson’s disease

Sofia A. Oliveira, Jeffery M Vance

Research output: Chapter in Book/Report/Conference proceedingChapter


Theories on the etiology of Parkinson disease (PD) have changed since its first description. In the famous James Parkinson monograph (1) that gave the disease its name, Parkinson reported that “affliction to indulgence in spirituous liquors, another to long lying on the damp ground” were among the suggested causes of the disease. Yet by 1888, Gowers (2) reported that 15% of his patients had a family history. Indeed, today most investigators accept that PD is due to a mixture of genetic and environmental influences interacting with each other, where the relative role of each may change from individual to individual.

Original languageEnglish (US)
Title of host publicationParkinson's Disease
Subtitle of host publicationGenetics and Pathogenesis
PublisherCRC Press
Number of pages14
ISBN (Electronic)9781420019223
ISBN (Print)9780849336973
StatePublished - Jan 1 2007

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Neuroscience(all)


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