Genetic polymorphisms related to behavioral approach and behavioral inhibition scales

Sheri L. Johnson; Charles S. Carver; Jutta Joormann; Michael L. Cuccaro

doi:10.1016/j.paid.2015.09.024

Genetic polymorphisms related to behavioral approach and behavioral inhibition scales

Sheri L. Johnson, Charles S. Carver, Jutta Joormann, Michael L. Cuccaro

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Genetic polymorphisms relevant to behavioral approach and behavioral inhibition are examined, using a polygenic approach while also considering the role of early adversity. Undergraduates (N. =. 343) completed the well-validated Behavioral Inhibition System/Behavioral Activation System (BIS/BAS) scales and provided blood for genotyping. The BDNF met allele was related to higher BIS scores. OPRM1 status interacted with a measure of early adversity to predict the BAS Reward Responsiveness subscale. Results provide additional support for the validity of the BIS/BAS scales, and suggest combined genetic and environmental influences on the development of these traits.

Original language	English (US)
Article number	7047
Pages (from-to)	251-255
Number of pages	5
Journal	Personality and Individual Differences
Volume	88
DOIs	https://doi.org/10.1016/j.paid.2015.09.024
State	Published - Jan 1 2016

Keywords

BDNF
Behavioral approach
Behavioral inhibition
Genetic polymorphism
OPRM1

ASJC Scopus subject areas

Psychology(all)

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title = "Genetic polymorphisms related to behavioral approach and behavioral inhibition scales",

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AU - Carver, Charles S.

AU - Joormann, Jutta

AU - Cuccaro, Michael L.

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AB - Genetic polymorphisms relevant to behavioral approach and behavioral inhibition are examined, using a polygenic approach while also considering the role of early adversity. Undergraduates (N. =. 343) completed the well-validated Behavioral Inhibition System/Behavioral Activation System (BIS/BAS) scales and provided blood for genotyping. The BDNF met allele was related to higher BIS scores. OPRM1 status interacted with a measure of early adversity to predict the BAS Reward Responsiveness subscale. Results provide additional support for the validity of the BIS/BAS scales, and suggest combined genetic and environmental influences on the development of these traits.

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KW - Behavioral inhibition

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