Genetic polymorphisms related to behavioral approach and behavioral inhibition scales

Sheri L. Johnson; Charles S. Carver; Jutta Joormann; Michael L. Cuccaro

doi:10.1016/j.paid.2015.09.024

Genetic polymorphisms related to behavioral approach and behavioral inhibition scales

Sheri L. Johnson, Charles S. Carver, Jutta Joormann, Michael L. Cuccaro

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9 Scopus citations

Abstract

Genetic polymorphisms relevant to behavioral approach and behavioral inhibition are examined, using a polygenic approach while also considering the role of early adversity. Undergraduates (N. =. 343) completed the well-validated Behavioral Inhibition System/Behavioral Activation System (BIS/BAS) scales and provided blood for genotyping. The BDNF met allele was related to higher BIS scores. OPRM1 status interacted with a measure of early adversity to predict the BAS Reward Responsiveness subscale. Results provide additional support for the validity of the BIS/BAS scales, and suggest combined genetic and environmental influences on the development of these traits.

Original language	English (US)
Pages (from-to)	251-255
Number of pages	5
Journal	Personality and Individual Differences
Volume	88
DOIs	https://doi.org/10.1016/j.paid.2015.09.024
State	Published - Jan 1 2016

Keywords

BDNF
Behavioral approach
Behavioral inhibition
Genetic polymorphism
OPRM1

ASJC Scopus subject areas

Psychology(all)

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10.1016/j.paid.2015.09.024

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@article{b43b356da6d84cb6af487ddbd570fe8b,

title = "Genetic polymorphisms related to behavioral approach and behavioral inhibition scales",

abstract = "Genetic polymorphisms relevant to behavioral approach and behavioral inhibition are examined, using a polygenic approach while also considering the role of early adversity. Undergraduates (N. =. 343) completed the well-validated Behavioral Inhibition System/Behavioral Activation System (BIS/BAS) scales and provided blood for genotyping. The BDNF met allele was related to higher BIS scores. OPRM1 status interacted with a measure of early adversity to predict the BAS Reward Responsiveness subscale. Results provide additional support for the validity of the BIS/BAS scales, and suggest combined genetic and environmental influences on the development of these traits.",

keywords = "BDNF, Behavioral approach, Behavioral inhibition, Genetic polymorphism, OPRM1",

author = "Johnson, {Sheri L.} and Carver, {Charles S.} and Jutta Joormann and Cuccaro, {Michael L.}",

note = "Funding Information: This work was made possible by seed funds associated with a University of Miami Distinguished Professorship . We are grateful to the staff at Hussman Institute for Human Genomics, particularly Ioanna Konidari, who carried out the genotyping. We are also thankful to Jennifer Nam, who played a major role in coordinating data collection, to Matthias Siemer, who consulted regarding analyses, and to Jordan Tharp, who formatted the manuscript. Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2016",

month = jan,

day = "1",

doi = "10.1016/j.paid.2015.09.024",

language = "English (US)",

volume = "88",

pages = "251--255",

journal = "Personality and Individual Differences",

issn = "0191-8869",

publisher = "Elsevier BV",

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TY - JOUR

T1 - Genetic polymorphisms related to behavioral approach and behavioral inhibition scales

AU - Johnson, Sheri L.

AU - Carver, Charles S.

AU - Joormann, Jutta

AU - Cuccaro, Michael L.

N1 - Funding Information: This work was made possible by seed funds associated with a University of Miami Distinguished Professorship . We are grateful to the staff at Hussman Institute for Human Genomics, particularly Ioanna Konidari, who carried out the genotyping. We are also thankful to Jennifer Nam, who played a major role in coordinating data collection, to Matthias Siemer, who consulted regarding analyses, and to Jordan Tharp, who formatted the manuscript. Publisher Copyright: © 2015 Elsevier Ltd.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Genetic polymorphisms relevant to behavioral approach and behavioral inhibition are examined, using a polygenic approach while also considering the role of early adversity. Undergraduates (N. =. 343) completed the well-validated Behavioral Inhibition System/Behavioral Activation System (BIS/BAS) scales and provided blood for genotyping. The BDNF met allele was related to higher BIS scores. OPRM1 status interacted with a measure of early adversity to predict the BAS Reward Responsiveness subscale. Results provide additional support for the validity of the BIS/BAS scales, and suggest combined genetic and environmental influences on the development of these traits.

AB - Genetic polymorphisms relevant to behavioral approach and behavioral inhibition are examined, using a polygenic approach while also considering the role of early adversity. Undergraduates (N. =. 343) completed the well-validated Behavioral Inhibition System/Behavioral Activation System (BIS/BAS) scales and provided blood for genotyping. The BDNF met allele was related to higher BIS scores. OPRM1 status interacted with a measure of early adversity to predict the BAS Reward Responsiveness subscale. Results provide additional support for the validity of the BIS/BAS scales, and suggest combined genetic and environmental influences on the development of these traits.

KW - BDNF

KW - Behavioral approach

KW - Behavioral inhibition

KW - Genetic polymorphism

KW - OPRM1

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DO - 10.1016/j.paid.2015.09.024

M3 - Article

AN - SCOPUS:84942543628

VL - 88

SP - 251

EP - 255

JO - Personality and Individual Differences

JF - Personality and Individual Differences

SN - 0191-8869

ER -

Genetic polymorphisms related to behavioral approach and behavioral inhibition scales

Abstract

Keywords

ASJC Scopus subject areas

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