Genetic polymorphisms as determinants for disease-preventive effects of vitamin E

Jean Marc Zingg, Angelo Azzi, Mohsen Meydani

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations

Abstract

Polymorphisms in genes involved in vitamin E uptake, distribution, metabolism, and molecular action may be important determinants for the protective effects of vitamin E supplementation. The haptoglobin 2-2 polymorphism is associated with increased production of oxygen free radicals and reduces levels of vitamin E and C; the consequent elevated risk for cardiovascular disease can be prevented by vitamin E supplementation.

Original languageEnglish (US)
Pages (from-to)406-414
Number of pages9
JournalNutrition Reviews
Volume66
Issue number7
DOIs
StatePublished - Jul 2008
Externally publishedYes

Keywords

  • α-tocopherol
  • Atherosclerosis
  • Haptoglobin
  • L-ascorbic acid
  • Polymorphisms

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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