Genetic influences and infantile autism [13]

Susan Folstein, Michael Rutter

Research output: Contribution to journalLetter

217 Scopus citations

Abstract

In his original description of infantile autism, Kanner suggested an 'inborn defect', because symptoms were often present from early infancy. Despite the rarity of a family history of autism and lack of an increase in parental consanguinity, there are two reasons for suspecting hereditary influences: the 2% rate of autism in siblings is 50 times that of the general population and a family history of speech delay is found in about a quarter of families. Reports of single pairs of twins with autism have not added much to our knowledge of genetic effects because of a bias toward reporting monozygotic (MZ) concordant pairs and because few reports contain both adequate clinical descriptions and evidence of zygosity. The authors undertook a study of a systematically collected sample of 21 pairs of same sexed twins, one or both of whom had autism as diagnosed by the criteria of Kanner and Rutter. The results reported here indicate the importance of hereditary influences in the aetiology of autism.

Original languageEnglish (US)
Pages (from-to)726-728
Number of pages3
JournalNature
Volume265
Issue number5596
DOIs
StatePublished - Dec 1 1977

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Genetic influences and infantile autism [13]'. Together they form a unique fingerprint.

  • Cite this

    Folstein, S., & Rutter, M. (1977). Genetic influences and infantile autism [13]. Nature, 265(5596), 726-728. https://doi.org/10.1038/265726a0