Genetic Factors and Susceptibility to Diabetic Nephropathy

Jonathan P. Tolins, Leopoldo Raij, S. Michael Mauer, Michael W. Steffes, David M. Brown, Andrzej S. Krolewski, Mitzy Canessa, James H. Warram, Lori M.b. Laffel, A. Richard Christlieb, William C. Knowler, Lawrence I. Rand, Giancarlo Viberti

Research output: Contribution to journalLetterpeer-review

8 Scopus citations


To the Editor: Krolewski et al.1 and Mangili et al.2 (Jan. 21 issue) propose that the cohort of patients with insulin-dependent diabetes mellitus in whom diabetic nephropathy is destined to develop may be composed of patients with a genetic predisposition to essential hypertension. Although the mechanism of this association may be difficult to determine in patients, some insight can be gained from the examination of data obtained from experimental models. In experimental diabetes in rats, renal vasodilatation, predominantly of the preglomerular resistance vessels, allows the transmission of systemic arterial pressure freely to the glomerular capillary, with subsequent hyperfiltration, hyperperfusion, and.

Original languageEnglish (US)
Pages (from-to)180-182
Number of pages3
JournalNew England Journal of Medicine
Issue number3
StatePublished - Jul 21 1988
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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