Abstract
The adult mouse brain contains complex populations of polyadenylated [poly(A)+] and nonpolyadenylated [poly(A)-] messenger RNA's (mRNA's). These mRNA's are separate sequence populations, similar in complexity, and in combination are equivalent to ~ 150,000 different mRNA sequences, of average length. Essentially all of the 'adult' poly(A)+ mRNA's are present in the brain at birth. In contrast, most of the poly(A)- mRNA's are absent. Brain poly(A)- mRNA's begin to appear soon after birth, but the full adult complement is not reached until young adulthood. This suggests that these poly(A)- mRNA's specify proteins required for the biological capabilities of the brain that emerge during the course of postnatal development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 924-928 |
| Number of pages | 5 |
| Journal | Science |
| Volume | 220 |
| Issue number | 4600 |
| DOIs | |
| State | Published - Jan 1 1983 |
| Externally published | Yes |
ASJC Scopus subject areas
- General
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Cite this
Chaudhari, N., & Hahn, W. E. (1983). Genetic expression in the developing brain. Science, 220(4600), 924-928. https://doi.org/10.1126/science.6189184