Genetic expression in the developing brain

Nirupa Chaudhari; William E. Hahn

doi:10.1126/science.6189184

Genetic expression in the developing brain

Nirupa Chaudhari, William E. Hahn

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

The adult mouse brain contains complex populations of polyadenylated [poly(A)⁺] and nonpolyadenylated [poly(A)^-] messenger RNA's (mRNA's). These mRNA's are separate sequence populations, similar in complexity, and in combination are equivalent to ~ 150,000 different mRNA sequences, of average length. Essentially all of the 'adult' poly(A)⁺ mRNA's are present in the brain at birth. In contrast, most of the poly(A)^- mRNA's are absent. Brain poly(A)^- mRNA's begin to appear soon after birth, but the full adult complement is not reached until young adulthood. This suggests that these poly(A)^- mRNA's specify proteins required for the biological capabilities of the brain that emerge during the course of postnatal development.

Original language	English (US)
Pages (from-to)	924-928
Number of pages	5
Journal	Science
Volume	220
Issue number	4600
DOIs	https://doi.org/10.1126/science.6189184
State	Published - Jan 1 1983
Externally published	Yes

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abstract = "The adult mouse brain contains complex populations of polyadenylated [poly(A)+] and nonpolyadenylated [poly(A)-] messenger RNA's (mRNA's). These mRNA's are separate sequence populations, similar in complexity, and in combination are equivalent to ~ 150,000 different mRNA sequences, of average length. Essentially all of the 'adult' poly(A)+ mRNA's are present in the brain at birth. In contrast, most of the poly(A)- mRNA's are absent. Brain poly(A)- mRNA's begin to appear soon after birth, but the full adult complement is not reached until young adulthood. This suggests that these poly(A)- mRNA's specify proteins required for the biological capabilities of the brain that emerge during the course of postnatal development.",

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AB - The adult mouse brain contains complex populations of polyadenylated [poly(A)+] and nonpolyadenylated [poly(A)-] messenger RNA's (mRNA's). These mRNA's are separate sequence populations, similar in complexity, and in combination are equivalent to ~ 150,000 different mRNA sequences, of average length. Essentially all of the 'adult' poly(A)+ mRNA's are present in the brain at birth. In contrast, most of the poly(A)- mRNA's are absent. Brain poly(A)- mRNA's begin to appear soon after birth, but the full adult complement is not reached until young adulthood. This suggests that these poly(A)- mRNA's specify proteins required for the biological capabilities of the brain that emerge during the course of postnatal development.

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