Genetic expression in the developing brain

Nirupa Chaudhari, William E. Hahn

Research output: Contribution to journalArticle

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Abstract

The adult mouse brain contains complex populations of polyadenylated [poly(A)+] and nonpolyadenylated [poly(A)-] messenger RNA's (mRNA's). These mRNA's are separate sequence populations, similar in complexity, and in combination are equivalent to ~ 150,000 different mRNA sequences, of average length. Essentially all of the 'adult' poly(A)+ mRNA's are present in the brain at birth. In contrast, most of the poly(A)- mRNA's are absent. Brain poly(A)- mRNA's begin to appear soon after birth, but the full adult complement is not reached until young adulthood. This suggests that these poly(A)- mRNA's specify proteins required for the biological capabilities of the brain that emerge during the course of postnatal development.

Original languageEnglish (US)
Pages (from-to)924-928
Number of pages5
JournalScience
Volume220
Issue number4600
DOIs
StatePublished - Jan 1 1983

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