Genetic expression in the developing brain

Nirupa Chaudhari, W. E. Hahn

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

The adult mouse brain contains complex populations of polyadenylated [poly(A)+] and nonpolyadenylated [poly(A)-] messenger RNA's (mRNA's). These mRNA's are separate sequence populations, similar in complexity, and in combination are equivalent to ~ 150,000 different mRNA sequences, of average length. Essentially all of the 'adult' poly(A)+ mRNA's are present in the brain at birth. In contrast, most of the poly(A)- mRNA's are absent. Brain poly(A)- mRNA's begin to appear soon after birth, but the full adult complement is not reached until young adulthood. This suggests that these poly(A)- mRNA's specify proteins required for the biological capabilities of the brain that emerge during the course of postnatal development.

Original languageEnglish
Pages (from-to)924-928
Number of pages5
JournalScience
Volume220
Issue number4600
StatePublished - Jan 1 1983
Externally publishedYes

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Messenger RNA
Brain
Parturition
Poly A
Population
Proteins

ASJC Scopus subject areas

  • General

Cite this

Chaudhari, N., & Hahn, W. E. (1983). Genetic expression in the developing brain. Science, 220(4600), 924-928.

Genetic expression in the developing brain. / Chaudhari, Nirupa; Hahn, W. E.

In: Science, Vol. 220, No. 4600, 01.01.1983, p. 924-928.

Research output: Contribution to journalArticle

Chaudhari, N & Hahn, WE 1983, 'Genetic expression in the developing brain', Science, vol. 220, no. 4600, pp. 924-928.
Chaudhari N, Hahn WE. Genetic expression in the developing brain. Science. 1983 Jan 1;220(4600):924-928.
Chaudhari, Nirupa ; Hahn, W. E. / Genetic expression in the developing brain. In: Science. 1983 ; Vol. 220, No. 4600. pp. 924-928.
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