Genetic evaluation of suspected cases of transient HIV-1 infection of infants

Lisa M. Frenkel, James I. Mullins, Gerald H. Learn, Laura Manns-Arcuino, Belinda L. Herring, Marcia L. Kalish, Richard W. Steketee, Donald M. Thea, Joan E. Nichols, Shan Lu Liu, Abdallah Harmache, Xi He, David Muthui, Anup Madan, Leroy Hood, Ashley T. Haase, Mary Zupancic, Katherine Staskus, Steven Wolinsky, Paul KrogstadJia Qi Zhao, Irvin Chen, Richard Koup, David Ho, Bette Korber, Raymond J. Apple, Robert W. Coombs, Savita Pahwa, Norbert J. Roberts

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51 Scopus citations

Abstract

Detection of human immunodeficiency virus-type 1 (HIV-1) on only one or a few occasions in infants born to infected mothers has been interpreted to indicate that infection may be transient rather than persistent. Forty-two cases of suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants and one mother were reanalyzed. HIV-1 env sequences were not found in specimens from 20; in specimens from 6, somatic genetic analysis revealed that specimens were mistakenly attributed to an infant; and in specimens from 17, phylogenetic analysis failed to demonstrate the expected linkage between the infant's and the mother's virus. These findings argue that transient HIV-1 infection, if it exists, will only rarely be satisfactorily documented.

Original languageEnglish (US)
Pages (from-to)1073-1077
Number of pages5
JournalScience
Volume280
Issue number5366
DOIs
StatePublished - May 15 1998

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    Frenkel, L. M., Mullins, J. I., Learn, G. H., Manns-Arcuino, L., Herring, B. L., Kalish, M. L., Steketee, R. W., Thea, D. M., Nichols, J. E., Liu, S. L., Harmache, A., He, X., Muthui, D., Madan, A., Hood, L., Haase, A. T., Zupancic, M., Staskus, K., Wolinsky, S., ... Roberts, N. J. (1998). Genetic evaluation of suspected cases of transient HIV-1 infection of infants. Science, 280(5366), 1073-1077. https://doi.org/10.1126/science.280.5366.1073