Genetic differences between adenocarcinomas arising in Barrett’s esophagus and gastric mucosa

Wael El-Rifai, Henry F. Frierson, Christopher A. Moskaluk, Jeffrey C. Harper, Gina R. Petroni, Eric A. Bissonette, David R. Jones, Sakari Knuutila, Steven M. Powell

Research output: Contribution to journalArticle

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Abstract

Background & Aims: Barrett adenocarcinoma (BA+) and gastric adenocarcinoma comprise a related group of neoplasms that nevertheless have some distinct clinicopathologic characteristics. This study aimed at defining critical molecular abnormalities that may underlie differences between BA+ and gastric adenocarcinomas. Methods: We used comparative genomic hybridization for the analyses of 34 xenografts of adenocarcinomas that arose from esophageal or gastric origin. Results: All tumors, except one, exhibited DNA copy number alterations. Losses in 4q and 14q and gains at 2p and 17q were more frequent in proximal (esophageal, gastroesophageal junction [GEJ], and cardia) tumors than in distal (body and antrum) tumors (P ≤ 0.050). These changes were significantly higher in BA+ compared with distal tumors (P ≤ 0.040). In addition, losses in 5q and gains at 20q were significantly higher in BA+ than in distal cancers (P ≤ 0.040). Losses in 5q and 8p and gains at 2q, 6p, 12p, and 20q were significantly more frequent in BA+ tumors (P ≤ 0.050) than in GEJ and cardiac tumors without associated Barrett's esophagus. Additionally, losses in 14q, which were common in proximal tumors, were more often seen in BA+ (P = 0.100) than in other proximal tumors. Conclusions: Although these adenocarcinomas share some common genetic alterations, the differences in the DNA copy numbers in BA+ cases suggest that unique genetic alterations may be involved in these cancers' development.

Original languageEnglish (US)
Pages (from-to)592-598
Number of pages7
JournalGastroenterology
Volume121
Issue number3
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

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Barrett Esophagus
Gastric Mucosa
Adenocarcinoma
Neoplasms
Esophagogastric Junction
Stomach
Esophageal Mucosa
Cardia
Heart Neoplasms
Comparative Genomic Hybridization
DNA
Heterografts

ASJC Scopus subject areas

  • Gastroenterology

Cite this

El-Rifai, W., Frierson, H. F., Moskaluk, C. A., Harper, J. C., Petroni, G. R., Bissonette, E. A., ... Powell, S. M. (2001). Genetic differences between adenocarcinomas arising in Barrett’s esophagus and gastric mucosa. Gastroenterology, 121(3), 592-598. https://doi.org/10.1053/gast.2001.27215

Genetic differences between adenocarcinomas arising in Barrett’s esophagus and gastric mucosa. / El-Rifai, Wael; Frierson, Henry F.; Moskaluk, Christopher A.; Harper, Jeffrey C.; Petroni, Gina R.; Bissonette, Eric A.; Jones, David R.; Knuutila, Sakari; Powell, Steven M.

In: Gastroenterology, Vol. 121, No. 3, 01.01.2001, p. 592-598.

Research output: Contribution to journalArticle

El-Rifai, W, Frierson, HF, Moskaluk, CA, Harper, JC, Petroni, GR, Bissonette, EA, Jones, DR, Knuutila, S & Powell, SM 2001, 'Genetic differences between adenocarcinomas arising in Barrett’s esophagus and gastric mucosa', Gastroenterology, vol. 121, no. 3, pp. 592-598. https://doi.org/10.1053/gast.2001.27215
El-Rifai, Wael ; Frierson, Henry F. ; Moskaluk, Christopher A. ; Harper, Jeffrey C. ; Petroni, Gina R. ; Bissonette, Eric A. ; Jones, David R. ; Knuutila, Sakari ; Powell, Steven M. / Genetic differences between adenocarcinomas arising in Barrett’s esophagus and gastric mucosa. In: Gastroenterology. 2001 ; Vol. 121, No. 3. pp. 592-598.
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AU - Bissonette, Eric A.

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AU - Knuutila, Sakari

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