Genetic differences between adenocarcinomas arising in Barrett’s esophagus and gastric mucosa

Wa’el El-Rifai, Henry F. Frierson, Christopher A. Moskaluk, Jeffrey C. Harper, Gina R. Petroni, Eric A. Bissonette, David R. Jones, Sakari Knuutila, Steven M. Powell

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

Background & Aims: Barrett adenocarcinoma (BA+) and gastric adenocarcinoma comprise a related group of neoplasms that nevertheless have some distinct clinicopathologic characteristics. This study aimed at defining critical molecular abnormalities that may underlie differences between BA+ and gastric adenocarcinomas. Methods: We used comparative genomic hybridization for the analyses of 34 xenografts of adenocarcinomas that arose from esophageal or gastric origin. Results: All tumors, except one, exhibited DNA copy number alterations. Losses in 4q and 14q and gains at 2p and 17q were more frequent in proximal (esophageal, gastroesophageal junction [GEJ], and cardia) tumors than in distal (body and antrum) tumors (P ≤ 0.050). These changes were significantly higher in BA+ compared with distal tumors (P ≤ 0.040). In addition, losses in 5q and gains at 20q were significantly higher in BA+ than in distal cancers (P ≤ 0.040). Losses in 5q and 8p and gains at 2q, 6p, 12p, and 20q were significantly more frequent in BA+ tumors (P ≤ 0.050) than in GEJ and cardiac tumors without associated Barrett's esophagus. Additionally, losses in 14q, which were common in proximal tumors, were more often seen in BA+ (P = 0.100) than in other proximal tumors. Conclusions: Although these adenocarcinomas share some common genetic alterations, the differences in the DNA copy numbers in BA+ cases suggest that unique genetic alterations may be involved in these cancers' development.

Original languageEnglish (US)
Pages (from-to)592-598
Number of pages7
JournalGastroenterology
Volume121
Issue number3
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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