Genetic control of T helper cell function in the clawed toad Xenopus laevis

Claude C.A. Bernard, Gérard Bordmann, Bonnie Blomberg, Louis Du Pasquier

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The genetic control of the collaboration between Xenopus T and B cells had been analyzed in vitro using cells from five strains of major histocompatibility complex-defined Xenopus. When carrier (fowl gamma-globulin)-primed T cells and hapten (dinitrophenylated keyhole limpet hemocyanin)-primed B cells differed by minor histocompatibility antigens or by only one haplotype of the major histocompatibility complex, the collaboration was efficient in the sense that large numbers of plaques, low-molecular weight antibodies and high-affinity IgM antibodies could be recorded in the cultures challenged with dinitrophenylated fowl gamma-globulin. However, when T and B cells differed at both alleles of the major histocompatibility complex, lower numbers of plaques were obtained, no low-molecular weight anti-hapten antibodies could be detected, and the IgM antibodies that were sometimes synthesized were of low affinity. This suggests that the major histocompatibility complex, or a gene linked with it, affects the collaboration between Xenopus T and B cells in a way perhaps similar to that described in mammals.

Original languageEnglish (US)
Pages (from-to)151-155
Number of pages5
JournalEuropean Journal of Immunology
Volume11
Issue number2
DOIs
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Genetic control of T helper cell function in the clawed toad Xenopus laevis'. Together they form a unique fingerprint.

  • Cite this