Genetic causes of nonsyndromic cleft lip with or without cleft palate

Qiuping Yuan, Susan H. Blanton, Jacqueline T. Hecht

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Scopus citations

Abstract

Nonsyndromic cleft lip with or without an associated cleft palate (NSCLP) is one of the most common birth defects affecting 135,000 babies worldwide each year. It causes severe facial dysmorphism and treatment requires a multifaceted team approach. While treatment modalities have improved, the costs to families and the health care resources are still enormous. The causes of NSCLP are multifactorial with both genetic and environmental factors. Progress is being made towards defining the genetic variation underpinning NSCLP by utilizing gene discovery techniques including genome wide linkage, association mapping and a candidate gene approaches. To date, approximately 20% of the genetic contributions to NSCLP have been assigned to a small number of genes. This chapter provides a review of recent progress in defining the genetic causes of NSCLP.

Original languageEnglish (US)
Title of host publicationMedical Genetics in the Clinical Practice of ORL
EditorsRaye Alford, Reid Sutton
Pages107-113
Number of pages7
DOIs
StatePublished - Mar 14 2011

Publication series

NameAdvances in Oto-Rhino-Laryngology
Volume70
ISSN (Print)0065-3071

ASJC Scopus subject areas

  • Otorhinolaryngology

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    Yuan, Q., Blanton, S. H., & Hecht, J. T. (2011). Genetic causes of nonsyndromic cleft lip with or without cleft palate. In R. Alford, & R. Sutton (Eds.), Medical Genetics in the Clinical Practice of ORL (pp. 107-113). (Advances in Oto-Rhino-Laryngology; Vol. 70). https://doi.org/10.1159/000322486