Genetic basis of hearing loss in Spanish, Hispanic and Latino populations

Rahul Mittal, Amit P. Patel, Desiree Nguyen, Debbie R. Pan, Vasanti M. Jhaveri, Jason R. Rudman, Arjuna Dharmaraja, Denise Yan, Yong Feng, Prem Chapagain, David J. Lee, Susan H. Blanton, Xue Zhong Liu

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Hearing loss (HL) is the most common neurosensory disorder affecting humans. The screening, prevention and treatment of HL require a better understanding of the underlying molecular mechanisms. Genetic predisposition is one of the most common factors that leads to HL. Most HL studies include few Spanish, Hispanic and Latino participants, leaving a critical gap in our understanding about the prevalence, impact, unmet health care needs, and genetic factors associated with hearing impairment among Spanish, Hispanic and Latino populations. The few studies which have been performed show that the gene variants commonly associated with HL in non-Spanish and non-Hispanic populations are infrequently responsible for hearing impairment in Spanish as well as Hispanic and Latino populations (hereafter referred to as Hispanic). To design effective screening tools to detect HL in Spanish and Hispanic populations, studies must be conducted to determine the gene variants that are most commonly associated with hearing impairment in this racial/ethnic group. In this review article, we summarize gene variants and loci associated with HL in Spanish and Hispanic populations. Identifying new genetic variants associated with HL in Spanish and Hispanic populations will pave the way to develop effective screening tools and therapeutic strategies for HL.

Original languageEnglish (US)
Pages (from-to)297-305
Number of pages9
StatePublished - Mar 20 2018


  • Genetic predisposition
  • Hearing loss
  • Hearing loss genes
  • Spanish population, Hispanic and Latino populations

ASJC Scopus subject areas

  • Genetics


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