Genetic and immune-related factors in the pathogenesis of lymphoproliferative and plasma cell malignancies

Sigurdur Y. Kristinsson, Lynn R. Goldin, Magnus Björkholm, Jill Koshiol, Ingemar Turesson, Ola Landgren

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

There are data to support a role for genetic and immunerelated factors in the pathogenesis of lymphomas and plasma cell diseases. In this paper, we review our published large population-based studies and other relevant studies in Hodgkin's and non-Hodgkin's lymphomas, multiple myeloma, and the precursor condition monoclonal gammopathy of undetermined significance. We discuss the overlap in risk factors between related malignancies and explore the underlying mechanisms. Based on these studies, we provide clinical implications and discuss the relevance of these data for patient counseling and clinical follow-up. Finally, we suggest future directions for new studies designed to increase our current knowledge and to define underlying biological mechanisms of our findings.

Original languageEnglish (US)
Pages (from-to)1581-1589
Number of pages9
JournalHaematologica
Volume94
Issue number11
DOIs
StatePublished - Nov 2009
Externally publishedYes

Keywords

  • Autoimmune disease
  • Chronic lymphocytic leukemia
  • Familial aggregation
  • Hodgkin's lymphoma
  • Immune-related
  • Lymphoma
  • Lymphoplasmacytic lymphoma
  • MGUS
  • Monoclonal B-cell lymphocytosis
  • Multiple myeloma
  • Non-Hodgkin's lymphoma
  • Rheumatoid arthritis
  • Susceptibility
  • Waldenström's macroglobulinemia

ASJC Scopus subject areas

  • Hematology

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