Genetic analysis on the role of integrin during axon guidance in Drosophila

Bao Hoang, Akira Chiba

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Heterodimeric cell surface receptor integrin is widely expressed in the nervous system, but its specific role during axon development has not been directly tested in vivo. We show that the Drosophila nervous system expresses low levels of positron-specific (PS) integrin subunits αPS1, αPS2, and βPS during embryonic axogenesis. Furthermore, certain subsets of neurons express higher levels of integrin mRNAs than do the rest. Null mutations in either the αPS1 or αPS2 subunit gene cause widespread axon pathfinding errors that can be rescued by supplying the wild-type integrin subunit to the mutant nervous system. In contrast, misexpressing either the αPS1 or αPS2 integrin subunit in all neurons leads to no obvious axon pathfinding errors. We propose that integrin does not itself serve as either a 'clutch' constituting molecule or a specific growth cone 'receptor,' as proposed previously, but rather as part of a molecular network that cooperatively guarantees accurate axon guidance.

Original languageEnglish (US)
Pages (from-to)7847-7855
Number of pages9
JournalJournal of Neuroscience
Issue number19
StatePublished - Oct 1 1998
Externally publishedYes


  • αPS1
  • αPS2
  • βPS
  • Axon guidance
  • Drosophila
  • Growth cone
  • Inflated
  • Integrin
  • Multiple edematous wings
  • Myospheroid
  • Neuromuscular
  • Pathfinding

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Genetic analysis on the role of integrin during axon guidance in Drosophila'. Together they form a unique fingerprint.

Cite this