Genetic aberrations in soft tissue leiomyosarcoma

Jilong Yang, Xiaoling Du, Kexin Chen, Antti Ylipää, Alexander J F Lazar, Jonathan Trent, Dina Lev, Raphael Pollock, Xishan Hao, Kelly Hunt, Wei Zhang

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

Leiomyosarcoma is a malignant mesenchymal tumor composed of cells showing smooth muscle differentiation. This tumor usually occurs in middle-aged or older adults, and forms a significant percentage of retroperitoneal, vascular, extremity, and uterine sarcomas. Leiomyosarcomas are most often associated with complex karyotypes with numerous chromosomal gains and losses. Some of these cytogenetic and molecular genetic aberrations correlate with histopathologic features and clinical outcomes. Identification of genetic alterations with specific identification of oncogenes and tumor suppressor genes may lead to additional insights into the tumorigenesis of leiomyosarcoma and the opportunity to confer the benefits of targeted therapy.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalCancer Letters
Volume275
Issue number1
DOIs
StatePublished - Mar 8 2009
Externally publishedYes

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Keywords

  • Array CGH
  • Genetic alteration
  • Karyotype
  • Leiomyosarcoma
  • Sarcoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Yang, J., Du, X., Chen, K., Ylipää, A., Lazar, A. J. F., Trent, J., Lev, D., Pollock, R., Hao, X., Hunt, K., & Zhang, W. (2009). Genetic aberrations in soft tissue leiomyosarcoma. Cancer Letters, 275(1), 1-8. https://doi.org/10.1016/j.canlet.2008.06.013