Genes and chronic obstructive pulmonary disease

Marilyn G. Foreman, Michael Campos, Juan C. Celedón

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


The marked variability in individual susceptibility to the detrimental effects of smoking on lung function and other findings suggest a significant genetic contribution to chronic obstructive pulmonary disease (COPD). The only known genetic risk factor for COPD, severe a 1-antitrypsin (AAT) deficiency, explains only 1% to 2% of cases of this disease. Screening for severe AAT should be done in all cases of COPD. There is considerable interest in identifying susceptibility genes for COPD unrelated to severe AAT deficiency, as this could greatly enhance efforts to prevent, diagnose, and treat COPD by yielding novel insights into its pathogenesis.

Original languageEnglish (US)
Pages (from-to)699-711
Number of pages13
JournalMedical Clinics of North America
Issue number4
StatePublished - Jul 2012


  • α -antitrypsin deficiency
  • COPD
  • Genetics

ASJC Scopus subject areas

  • Medicine(all)


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