Generalized Quasi-Likelihood Ratio Tests for Semiparametric Analysis of Covariance Models in Longitudinal Data

Jin Tang, Yehua Li, Yongtao Guan

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


We model generalized longitudinal data from multiple treatment groups by a class of semiparametric analysis of covariance models, which take into account the parametric effects of time dependent covariates and the nonparametric time effects. In these models, the treatment effects are represented by nonparametric functions of time and we propose a generalized quasi-likelihood ratio test procedure to test if these functions are identical. Our estimation procedure is based on profile estimating equations combined with local linear smoothers. We find that the much celebrated Wilks phenomenon which is well established for independent data still holds for longitudinal data if a working independence correlation structure is assumed in the test statistic. However, this property does not hold in general, especially when the working variance function is misspecified. Our empirical study also shows that incorporating correlation into the test statistic does not necessarily improve the power of the test. The proposed methods are illustrated with simulation studies and a real application from opioid dependence treatments. Supplementary materials for this article are available online.

Original languageEnglish (US)
Pages (from-to)736-747
Number of pages12
JournalJournal of the American Statistical Association
Issue number514
StatePublished - Apr 2 2016
Externally publishedYes


  • Analysis of variance
  • Functional data
  • Hypothesis testing
  • Kernel smoothing
  • Longitudinal data
  • Semiparametric

ASJC Scopus subject areas

  • Statistics and Probability
  • Statistics, Probability and Uncertainty


Dive into the research topics of 'Generalized Quasi-Likelihood Ratio Tests for Semiparametric Analysis of Covariance Models in Longitudinal Data'. Together they form a unique fingerprint.

Cite this