Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex

Philip A. Kragel, Michiko Kano, Lukas Van Oudenhove, Huynh Giao Ly, Patrick Dupont, Amandine Rubio, Chantal Delon-Martin, Bruno L. Bonaz, Stephen B. Manuck, Peter J. Gianaros, Marta Ceko, Elizabeth Losin, Choong Wan Woo, Thomas E. Nichols, Tor D. Wager

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The medial frontal cortex, including anterior midcingulate cortex, has been linked to multiple psychological domains, including cognitive control, pain, and emotion. However, it is unclear whether this region encodes representations of these domains that are generalizable across studies and subdomains. Additionally, if there are generalizable representations, do they reflect a single underlying process shared across domains or multiple domain-specific processes? We decomposed multivariate patterns of functional MRI activity from 270 participants across 18 studies into study-specific, subdomain-specific, and domain-specific components and identified latent multivariate representations that generalized across subdomains but were specific to each domain. Pain representations were localized to anterior midcingulate cortex, negative emotion representations to ventromedial prefrontal cortex, and cognitive control representations to portions of the dorsal midcingulate. These findings provide evidence for medial frontal cortex representations that generalize across studies and subdomains but are specific to distinct psychological domains rather than reducible to a single underlying process.

Original languageEnglish (US)
Pages (from-to)283-289
Number of pages7
JournalNature Neuroscience
Volume21
Issue number2
DOIs
StatePublished - Feb 1 2018

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Frontal Lobe
Emotions
Psychology
Pain
Prefrontal Cortex
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kragel, P. A., Kano, M., Van Oudenhove, L., Ly, H. G., Dupont, P., Rubio, A., ... Wager, T. D. (2018). Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex. Nature Neuroscience, 21(2), 283-289. https://doi.org/10.1038/s41593-017-0051-7

Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex. / Kragel, Philip A.; Kano, Michiko; Van Oudenhove, Lukas; Ly, Huynh Giao; Dupont, Patrick; Rubio, Amandine; Delon-Martin, Chantal; Bonaz, Bruno L.; Manuck, Stephen B.; Gianaros, Peter J.; Ceko, Marta; Losin, Elizabeth; Woo, Choong Wan; Nichols, Thomas E.; Wager, Tor D.

In: Nature Neuroscience, Vol. 21, No. 2, 01.02.2018, p. 283-289.

Research output: Contribution to journalArticle

Kragel, PA, Kano, M, Van Oudenhove, L, Ly, HG, Dupont, P, Rubio, A, Delon-Martin, C, Bonaz, BL, Manuck, SB, Gianaros, PJ, Ceko, M, Losin, E, Woo, CW, Nichols, TE & Wager, TD 2018, 'Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex', Nature Neuroscience, vol. 21, no. 2, pp. 283-289. https://doi.org/10.1038/s41593-017-0051-7
Kragel, Philip A. ; Kano, Michiko ; Van Oudenhove, Lukas ; Ly, Huynh Giao ; Dupont, Patrick ; Rubio, Amandine ; Delon-Martin, Chantal ; Bonaz, Bruno L. ; Manuck, Stephen B. ; Gianaros, Peter J. ; Ceko, Marta ; Losin, Elizabeth ; Woo, Choong Wan ; Nichols, Thomas E. ; Wager, Tor D. / Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex. In: Nature Neuroscience. 2018 ; Vol. 21, No. 2. pp. 283-289.
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