General biological aspects of oncogenesis

Gina D'Amato, Roberto Patarca

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Both genetic and epigenetic events play an important role in oncogenic processes. This review discusses the four hypothesis for the origin of neoplastic transformation (mutational genetic, nonmutational genetic, viral, and epigenetic) in the context of a summary of our current knowledge of the pathobiology of cancer.

Original languageEnglish (US)
Pages (from-to)275-373
Number of pages99
JournalCritical reviews in oncogenesis
Issue number3-4
StatePublished - 1998


  • Metastasis
  • Oncogenes
  • Tumor suppressor genes

ASJC Scopus subject areas

  • Cancer Research


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