General anesthesia during percutaneous transluminary coronary angioplasty for acute myocardial infarction: Results of a randomized controlled clinical trial

N. P. De Bruijn, M. A. Hlatky, J. R. Jacobs, F. M. Clements, N. D. Croughwell, D. Davis, P. Flezzani, R. F. Hill, T. Hinohara, R. A. Kates, J. H. Karis, W. McIntyre, J. G. Reves, R. S. Stack

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Acutely ill patients with myocardial infarction may require immediate cardiac catheterization and coronary angioplasty to achieve myocardial reperfusion. To determine the feasibility of using general anesthesia under these circumstances, a randomized clinical trial was performed. Of 50 patients, 25 received anesthesia and 25 received intravenous sedation. There were transient increases in heart rate and blood pressure after tracheal intubation in the anesthetized patients, followed by significant and sustained decreases below baseline values once steady state anesthesia was attained. Arterial oxygenation was significantly improved in anesthetized patients. There were no serious complications due to anesthesia, but the small sample size limited the power of the study to detect differences in morbidity or mortality. Patients strongly preferred anesthesia. These results show that general anesthesia is feasible in patients undergoing interventional cardiac catheterization during acute myocardial infarction, when pain, anxiety, or agitation do not respond adequately to conventional measures.

Original languageEnglish
Pages (from-to)201-207
Number of pages7
JournalAnesthesia and Analgesia
Volume68
Issue number3
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Angioplasty
General Anesthesia
Randomized Controlled Trials
Myocardial Infarction
Anesthesia
Cardiac Catheterization
Myocardial Reperfusion
Intubation
Sample Size
Anxiety
Heart Rate
Blood Pressure
Morbidity
Pain
Mortality

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

De Bruijn, N. P., Hlatky, M. A., Jacobs, J. R., Clements, F. M., Croughwell, N. D., Davis, D., ... Stack, R. S. (1989). General anesthesia during percutaneous transluminary coronary angioplasty for acute myocardial infarction: Results of a randomized controlled clinical trial. Anesthesia and Analgesia, 68(3), 201-207.

General anesthesia during percutaneous transluminary coronary angioplasty for acute myocardial infarction : Results of a randomized controlled clinical trial. / De Bruijn, N. P.; Hlatky, M. A.; Jacobs, J. R.; Clements, F. M.; Croughwell, N. D.; Davis, D.; Flezzani, P.; Hill, R. F.; Hinohara, T.; Kates, R. A.; Karis, J. H.; McIntyre, W.; Reves, J. G.; Stack, R. S.

In: Anesthesia and Analgesia, Vol. 68, No. 3, 01.01.1989, p. 201-207.

Research output: Contribution to journalArticle

De Bruijn, NP, Hlatky, MA, Jacobs, JR, Clements, FM, Croughwell, ND, Davis, D, Flezzani, P, Hill, RF, Hinohara, T, Kates, RA, Karis, JH, McIntyre, W, Reves, JG & Stack, RS 1989, 'General anesthesia during percutaneous transluminary coronary angioplasty for acute myocardial infarction: Results of a randomized controlled clinical trial', Anesthesia and Analgesia, vol. 68, no. 3, pp. 201-207.
De Bruijn, N. P. ; Hlatky, M. A. ; Jacobs, J. R. ; Clements, F. M. ; Croughwell, N. D. ; Davis, D. ; Flezzani, P. ; Hill, R. F. ; Hinohara, T. ; Kates, R. A. ; Karis, J. H. ; McIntyre, W. ; Reves, J. G. ; Stack, R. S. / General anesthesia during percutaneous transluminary coronary angioplasty for acute myocardial infarction : Results of a randomized controlled clinical trial. In: Anesthesia and Analgesia. 1989 ; Vol. 68, No. 3. pp. 201-207.
@article{48a40162a05144118f0a38e637d715f2,
title = "General anesthesia during percutaneous transluminary coronary angioplasty for acute myocardial infarction: Results of a randomized controlled clinical trial",
abstract = "Acutely ill patients with myocardial infarction may require immediate cardiac catheterization and coronary angioplasty to achieve myocardial reperfusion. To determine the feasibility of using general anesthesia under these circumstances, a randomized clinical trial was performed. Of 50 patients, 25 received anesthesia and 25 received intravenous sedation. There were transient increases in heart rate and blood pressure after tracheal intubation in the anesthetized patients, followed by significant and sustained decreases below baseline values once steady state anesthesia was attained. Arterial oxygenation was significantly improved in anesthetized patients. There were no serious complications due to anesthesia, but the small sample size limited the power of the study to detect differences in morbidity or mortality. Patients strongly preferred anesthesia. These results show that general anesthesia is feasible in patients undergoing interventional cardiac catheterization during acute myocardial infarction, when pain, anxiety, or agitation do not respond adequately to conventional measures.",
author = "{De Bruijn}, {N. P.} and Hlatky, {M. A.} and Jacobs, {J. R.} and Clements, {F. M.} and Croughwell, {N. D.} and D. Davis and P. Flezzani and Hill, {R. F.} and T. Hinohara and Kates, {R. A.} and Karis, {J. H.} and W. McIntyre and Reves, {J. G.} and Stack, {R. S.}",
year = "1989",
month = "1",
day = "1",
language = "English",
volume = "68",
pages = "201--207",
journal = "Anesthesia and Analgesia",
issn = "0003-2999",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - General anesthesia during percutaneous transluminary coronary angioplasty for acute myocardial infarction

T2 - Results of a randomized controlled clinical trial

AU - De Bruijn, N. P.

AU - Hlatky, M. A.

AU - Jacobs, J. R.

AU - Clements, F. M.

AU - Croughwell, N. D.

AU - Davis, D.

AU - Flezzani, P.

AU - Hill, R. F.

AU - Hinohara, T.

AU - Kates, R. A.

AU - Karis, J. H.

AU - McIntyre, W.

AU - Reves, J. G.

AU - Stack, R. S.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Acutely ill patients with myocardial infarction may require immediate cardiac catheterization and coronary angioplasty to achieve myocardial reperfusion. To determine the feasibility of using general anesthesia under these circumstances, a randomized clinical trial was performed. Of 50 patients, 25 received anesthesia and 25 received intravenous sedation. There were transient increases in heart rate and blood pressure after tracheal intubation in the anesthetized patients, followed by significant and sustained decreases below baseline values once steady state anesthesia was attained. Arterial oxygenation was significantly improved in anesthetized patients. There were no serious complications due to anesthesia, but the small sample size limited the power of the study to detect differences in morbidity or mortality. Patients strongly preferred anesthesia. These results show that general anesthesia is feasible in patients undergoing interventional cardiac catheterization during acute myocardial infarction, when pain, anxiety, or agitation do not respond adequately to conventional measures.

AB - Acutely ill patients with myocardial infarction may require immediate cardiac catheterization and coronary angioplasty to achieve myocardial reperfusion. To determine the feasibility of using general anesthesia under these circumstances, a randomized clinical trial was performed. Of 50 patients, 25 received anesthesia and 25 received intravenous sedation. There were transient increases in heart rate and blood pressure after tracheal intubation in the anesthetized patients, followed by significant and sustained decreases below baseline values once steady state anesthesia was attained. Arterial oxygenation was significantly improved in anesthetized patients. There were no serious complications due to anesthesia, but the small sample size limited the power of the study to detect differences in morbidity or mortality. Patients strongly preferred anesthesia. These results show that general anesthesia is feasible in patients undergoing interventional cardiac catheterization during acute myocardial infarction, when pain, anxiety, or agitation do not respond adequately to conventional measures.

UR - http://www.scopus.com/inward/record.url?scp=0024598978&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024598978&partnerID=8YFLogxK

M3 - Article

C2 - 2521988

AN - SCOPUS:0024598978

VL - 68

SP - 201

EP - 207

JO - Anesthesia and Analgesia

JF - Anesthesia and Analgesia

SN - 0003-2999

IS - 3

ER -