General anesthesia during percutaneous transluminary coronary angioplasty for acute myocardial infarction: Results of a randomized controlled clinical trial

N. P. De Bruijn, M. A. Hlatky, J. R. Jacobs, F. M. Clements, N. D. Croughwell, D. Davis, P. Flezzani, R. F. Hill, T. Hinohara, R. A. Kates, J. H. Karis, W. McIntyre, J. G. Reves, R. S. Stack

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Acutely ill patients with myocardial infarction may require immediate cardiac catheterization and coronary angioplasty to achieve myocardial reperfusion. To determine the feasibility of using general anesthesia under these circumstances, a randomized clinical trial was performed. Of 50 patients, 25 received anesthesia and 25 received intravenous sedation. There were transient increases in heart rate and blood pressure after tracheal intubation in the anesthetized patients, followed by significant and sustained decreases below baseline values once steady state anesthesia was attained. Arterial oxygenation was significantly improved in anesthetized patients. There were no serious complications due to anesthesia, but the small sample size limited the power of the study to detect differences in morbidity or mortality. Patients strongly preferred anesthesia. These results show that general anesthesia is feasible in patients undergoing interventional cardiac catheterization during acute myocardial infarction, when pain, anxiety, or agitation do not respond adequately to conventional measures.

Original languageEnglish (US)
Pages (from-to)201-207
Number of pages7
JournalAnesthesia and analgesia
Volume68
Issue number3
StatePublished - 1989

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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