Gene transfer of glutamic acid decarboxylase reduces neuropathic pain

Shuanglin Hao, Marina Mata, Darren Wolfe, Joseph C. Glorioso, David J. Fink

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

We tested whether transfer of the gene coding for glutamic acid decarboxylase to dorsal root ganglion using a herpes simplex virus vector to achieve release of GABA in dorsal horn would attenuate nociception in this condition. Subcutaneous inoculation of a replication-defective herpes simplex virus vector expressing glutamic acid decarboxylase (vector QHGAD67) 7 days after selective L5 spinal nerve ligation reversed mechanical allodynia and thermal hyperalgesia; the antiallodynic effect lasted 6 weeks and was reestablished by reinoculation. QHGAD67 inoculation also suppressed induction of c-Fos and phosphorylated extracellular signal-regulated kinase 1 and 2 in the spinal cord.

Original languageEnglish (US)
Pages (from-to)914-918
Number of pages5
JournalAnnals of neurology
Volume57
Issue number6
DOIs
StatePublished - Jun 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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