Gene structure of human cardiac hormone precursor, pronatriodilatin

M. Nemer, M. Chamberland, D. Sirois, S. Argentin, J. Drouin, R. A. Dixon, R. A. Zivin, J. H. Condra

Research output: Contribution to journalArticle

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Abstract

Atrial cardiocytes contain granules typical of protein-secreting cells, and atrial extracts are known to contain a powerful natriuretic and diuretic activity and to possess smooth muscle relaxant activity. A variety of active atrial peptides have been isolated, including a family of related peptides showing natriuretic, diuretic and smooth muscle relaxant activities in rat and human atria; these peptides were named atrial natriuretic factor (ANF). Another unrelated peptide from pig atria, cardiodilatin, is thought to posses only smooth muscle relaxant activity. Its partial amino acid sequence shows no homology with ANF sequences. The sequence analysis of a large form (106 amino acids) of ANF and of ANF complementary DNA clones indicates that cardiodilatin and ANF peptides are synthesized from a common precursor. This precursor also contains a signal peptide sequence expected of a secretory protein. We now describe the complete structure and sequence of the human gene for this novel hormone precursor that we call pronatriodilatin.

Original languageEnglish
Pages (from-to)654-656
Number of pages3
JournalNature
Volume312
Issue number5995
DOIs
StatePublished - Dec 1 1984

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Atrial Natriuretic Factor
Hormones
Genes
Smooth Muscle
Diuretics
Natriuretic Peptides
Peptides
Protein Sorting Signals
Cell Extracts
Sequence Analysis
Amino Acid Sequence
Proteins
Swine
Complementary DNA
Clone Cells
Amino Acids

ASJC Scopus subject areas

  • General

Cite this

Nemer, M., Chamberland, M., Sirois, D., Argentin, S., Drouin, J., Dixon, R. A., ... Condra, J. H. (1984). Gene structure of human cardiac hormone precursor, pronatriodilatin. Nature, 312(5995), 654-656. https://doi.org/10.1038/312654a0

Gene structure of human cardiac hormone precursor, pronatriodilatin. / Nemer, M.; Chamberland, M.; Sirois, D.; Argentin, S.; Drouin, J.; Dixon, R. A.; Zivin, R. A.; Condra, J. H.

In: Nature, Vol. 312, No. 5995, 01.12.1984, p. 654-656.

Research output: Contribution to journalArticle

Nemer, M, Chamberland, M, Sirois, D, Argentin, S, Drouin, J, Dixon, RA, Zivin, RA & Condra, JH 1984, 'Gene structure of human cardiac hormone precursor, pronatriodilatin', Nature, vol. 312, no. 5995, pp. 654-656. https://doi.org/10.1038/312654a0
Nemer M, Chamberland M, Sirois D, Argentin S, Drouin J, Dixon RA et al. Gene structure of human cardiac hormone precursor, pronatriodilatin. Nature. 1984 Dec 1;312(5995):654-656. https://doi.org/10.1038/312654a0
Nemer, M. ; Chamberland, M. ; Sirois, D. ; Argentin, S. ; Drouin, J. ; Dixon, R. A. ; Zivin, R. A. ; Condra, J. H. / Gene structure of human cardiac hormone precursor, pronatriodilatin. In: Nature. 1984 ; Vol. 312, No. 5995. pp. 654-656.
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