Gene profiling: Implications in dermatology

Miroslav Blumenberg, Marjana Tomic-Canic

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

DNA microarrays are capable of following the level of expression of virtually all genes in a human tissue. This has been employed to determine aberrant gene-expression profiles in many skin diseases, including UV-light damage, inflammatory processes and cancers. Owing to its accessibility, skin served as one of the initial targets of basic research using DNA microarrays; both the epidermis and dermis have been extensively investigated. Development of bedside uses of DNA arrays, coupled with the concomitant price reduction of the materials and methods of microarray analyses, holds great promise for improved diagnosis, treatment and prevention of dermatologic disorders.

Original languageEnglish (US)
Pages (from-to)763-768
Number of pages6
JournalExpert Review of Dermatology
Volume2
Issue number6
DOIs
StatePublished - Dec 2007

Keywords

  • Cytokines
  • DNA microarrays
  • Melanoma
  • Psoriasis
  • Transcriptional profiling
  • UV light

ASJC Scopus subject areas

  • Dermatology

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