Gene Expression Analysis of Cardiovascular Diseases. Novel Insights Into Biology and Clinical Applications

David M Seo, Geoffrey S. Ginsburg, Pascal Goldschmidt-Clermont

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Although the contribution of genetics to complex cardiovascular diseases such as atherosclerosis has been accepted for quite some time, full and detailed knowledge of the individual causative genes has been elusive. With the advent of genomic technologies and methods, the necessary tools are now available to begin pinpointing the genes that contribute to disease susceptibility and progression. One approach being applied extensively in candidate gene discovery is gene expression analysis of human and animal tissues using microarrays. The genes identified by these genomic studies provide valuable insight into disease biology and represent the initial steps toward the development of diagnostic tests and therapeutic strategies that will substantially improve human health. This paper highlights the progress that has been made in using gene expression analysis cardiovascular genomic research and the potential for applying these findings in clinical medicine.

Original languageEnglish
Pages (from-to)227-235
Number of pages9
JournalJournal of the American College of Cardiology
Volume48
Issue number2
DOIs
StatePublished - Jul 18 2006
Externally publishedYes

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Cardiovascular Diseases
Gene Expression
Genes
Clinical Medicine
Disease Susceptibility
Genetic Association Studies
Routine Diagnostic Tests
Disease Progression
Atherosclerosis
Technology
Health
Research
Therapeutics

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Gene Expression Analysis of Cardiovascular Diseases. Novel Insights Into Biology and Clinical Applications. / Seo, David M; Ginsburg, Geoffrey S.; Goldschmidt-Clermont, Pascal.

In: Journal of the American College of Cardiology, Vol. 48, No. 2, 18.07.2006, p. 227-235.

Research output: Contribution to journalArticle

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