Abstract
Genome-wide association studies (GWAS) of obesity measures have identified associations with single nucleotide polymorphisms (SNPs). However, no large-scale evaluation of gene-environment interactions has been performed. We conducted a search of gene-environment (G × E) interactions in post-menopausal African-American and Hispanic women from the Women's Health Initiative SNP Health Association Resource GWAS study. Single SNP linear regression on body mass index (BMI) and waist-to-hip circumference ratio (WHR) adjusted for multidimensional-scaling-derived axes of ancestry and age was run in race-stratified data with 871,512 SNPs available from African-Americans (N = 8,203) and 786,776 SNPs from Hispanics (N = 3,484). Tests of G × E interaction at all SNPs for recreational physical activity (m h/week), dietary energy intake (kcal/day), alcohol intake (categorical), cigarette smoking years, and cigarette smoking (ever vs. never) were run in African-Americans and Hispanics adjusted for ancestry and age at interview, followed by meta-analysis of G × E interaction terms. The strongest evidence for concordant G × E interactions in African-Americans and Hispanics was for smoking and marker rs10133840 (Q statistic P = 0.70, beta = -0.01, P = 3.81 × 10 -7) with BMI as the outcome. The strongest evidence for G × E interaction within a cohort was in African-Americans with WHR as outcome for dietary energy intake and rs9557704 (SNP × kcal = -0.04, P = 2.17 × 10-7). No results exceeded the Bonferroni-corrected statistical significance threshold.
| Original language | English |
|---|---|
| Pages (from-to) | 323-336 |
| Number of pages | 14 |
| Journal | Human Genetics |
| Volume | 132 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2013 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics(clinical)
- Genetics
Cite this
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study. / Velez Edwards, Digna R.; Naj, Adam C.; Monda, Keri; North, Kari E.; Neuhouser, Marian; Magvanjav, Oyunbileg; Kusimo, Ibukun; Vitolins, Mara Z.; Manson, Joann E.; O'Sullivan, Mary Jo; Rampersaud, Evadnie; Edwards, Todd L.
In: Human Genetics, Vol. 132, No. 3, 01.03.2013, p. 323-336.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study
AU - Velez Edwards, Digna R.
AU - Naj, Adam C.
AU - Monda, Keri
AU - North, Kari E.
AU - Neuhouser, Marian
AU - Magvanjav, Oyunbileg
AU - Kusimo, Ibukun
AU - Vitolins, Mara Z.
AU - Manson, Joann E.
AU - O'Sullivan, Mary Jo
AU - Rampersaud, Evadnie
AU - Edwards, Todd L.
PY - 2013/3/1
Y1 - 2013/3/1
N2 - Genome-wide association studies (GWAS) of obesity measures have identified associations with single nucleotide polymorphisms (SNPs). However, no large-scale evaluation of gene-environment interactions has been performed. We conducted a search of gene-environment (G × E) interactions in post-menopausal African-American and Hispanic women from the Women's Health Initiative SNP Health Association Resource GWAS study. Single SNP linear regression on body mass index (BMI) and waist-to-hip circumference ratio (WHR) adjusted for multidimensional-scaling-derived axes of ancestry and age was run in race-stratified data with 871,512 SNPs available from African-Americans (N = 8,203) and 786,776 SNPs from Hispanics (N = 3,484). Tests of G × E interaction at all SNPs for recreational physical activity (m h/week), dietary energy intake (kcal/day), alcohol intake (categorical), cigarette smoking years, and cigarette smoking (ever vs. never) were run in African-Americans and Hispanics adjusted for ancestry and age at interview, followed by meta-analysis of G × E interaction terms. The strongest evidence for concordant G × E interactions in African-Americans and Hispanics was for smoking and marker rs10133840 (Q statistic P = 0.70, beta = -0.01, P = 3.81 × 10 -7) with BMI as the outcome. The strongest evidence for G × E interaction within a cohort was in African-Americans with WHR as outcome for dietary energy intake and rs9557704 (SNP × kcal = -0.04, P = 2.17 × 10-7). No results exceeded the Bonferroni-corrected statistical significance threshold.
AB - Genome-wide association studies (GWAS) of obesity measures have identified associations with single nucleotide polymorphisms (SNPs). However, no large-scale evaluation of gene-environment interactions has been performed. We conducted a search of gene-environment (G × E) interactions in post-menopausal African-American and Hispanic women from the Women's Health Initiative SNP Health Association Resource GWAS study. Single SNP linear regression on body mass index (BMI) and waist-to-hip circumference ratio (WHR) adjusted for multidimensional-scaling-derived axes of ancestry and age was run in race-stratified data with 871,512 SNPs available from African-Americans (N = 8,203) and 786,776 SNPs from Hispanics (N = 3,484). Tests of G × E interaction at all SNPs for recreational physical activity (m h/week), dietary energy intake (kcal/day), alcohol intake (categorical), cigarette smoking years, and cigarette smoking (ever vs. never) were run in African-Americans and Hispanics adjusted for ancestry and age at interview, followed by meta-analysis of G × E interaction terms. The strongest evidence for concordant G × E interactions in African-Americans and Hispanics was for smoking and marker rs10133840 (Q statistic P = 0.70, beta = -0.01, P = 3.81 × 10 -7) with BMI as the outcome. The strongest evidence for G × E interaction within a cohort was in African-Americans with WHR as outcome for dietary energy intake and rs9557704 (SNP × kcal = -0.04, P = 2.17 × 10-7). No results exceeded the Bonferroni-corrected statistical significance threshold.
UR - http://www.scopus.com/inward/record.url?scp=84875634736&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875634736&partnerID=8YFLogxK
U2 - 10.1007/s00439-012-1246-3
DO - 10.1007/s00439-012-1246-3
M3 - Article
C2 - 23192594
AN - SCOPUS:84875634736
VL - 132
SP - 323
EP - 336
JO - Human Genetics
JF - Human Genetics
SN - 0340-6717
IS - 3
ER -