Abstract
Several polymorphisms relevant to dopamine and serotonin have been identified as potential contributors to individual differences in impulsivity versus self-control. Because impulsivity is a multifaceted construct, a need remains to examine more closely how various genes relate to different aspects of impulsivity. We examined four dopamine-related polymorphisms and the serotonin transporter as predictors of three aspects of impulsivity, two bearing on impulsive reactions to emotions and one on difficulty in completing intended actions. Early adversity was also examined as a potentiator of genetic effects. Undergraduates completed measures of impulsivity and early adversity and were genotyped. COMT, BDNF, DRD4, and 5HTTLPR (the latter two in interaction with early adversity) made independent contributions to prediction of Pervasive Influence of Feelings. BDNF made a contribution to Lack of Follow-Through. ANKK1 and 5HTTLPR (both in interaction with early adversity) made independent contributions to Feelings Trigger Action. Thus, five polymorphisms contributed to predicting impulsivity, but different polymorphisms related to different aspects.
| Original language | English |
|---|---|
| Pages (from-to) | 730-739 |
| Number of pages | 10 |
| Journal | Social Psychological and Personality Science |
| Volume | 5 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 2014 |
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Keywords
- 5HTTLPR
- ANKK1
- BDNF
- COMT
- DRD4
- impulsiveness
ASJC Scopus subject areas
- Social Psychology
- Clinical Psychology
Cite this
Gene Effects and G × E Interactions in the Differential Prediction of Three Aspects of Impulsiveness. / Carver, Charles S; LeMoult, Joelle; Johnson, Sheri L.; Joormann, Jutta.
In: Social Psychological and Personality Science, Vol. 5, No. 6, 01.01.2014, p. 730-739.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gene Effects and G × E Interactions in the Differential Prediction of Three Aspects of Impulsiveness
AU - Carver, Charles S
AU - LeMoult, Joelle
AU - Johnson, Sheri L.
AU - Joormann, Jutta
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Several polymorphisms relevant to dopamine and serotonin have been identified as potential contributors to individual differences in impulsivity versus self-control. Because impulsivity is a multifaceted construct, a need remains to examine more closely how various genes relate to different aspects of impulsivity. We examined four dopamine-related polymorphisms and the serotonin transporter as predictors of three aspects of impulsivity, two bearing on impulsive reactions to emotions and one on difficulty in completing intended actions. Early adversity was also examined as a potentiator of genetic effects. Undergraduates completed measures of impulsivity and early adversity and were genotyped. COMT, BDNF, DRD4, and 5HTTLPR (the latter two in interaction with early adversity) made independent contributions to prediction of Pervasive Influence of Feelings. BDNF made a contribution to Lack of Follow-Through. ANKK1 and 5HTTLPR (both in interaction with early adversity) made independent contributions to Feelings Trigger Action. Thus, five polymorphisms contributed to predicting impulsivity, but different polymorphisms related to different aspects.
AB - Several polymorphisms relevant to dopamine and serotonin have been identified as potential contributors to individual differences in impulsivity versus self-control. Because impulsivity is a multifaceted construct, a need remains to examine more closely how various genes relate to different aspects of impulsivity. We examined four dopamine-related polymorphisms and the serotonin transporter as predictors of three aspects of impulsivity, two bearing on impulsive reactions to emotions and one on difficulty in completing intended actions. Early adversity was also examined as a potentiator of genetic effects. Undergraduates completed measures of impulsivity and early adversity and were genotyped. COMT, BDNF, DRD4, and 5HTTLPR (the latter two in interaction with early adversity) made independent contributions to prediction of Pervasive Influence of Feelings. BDNF made a contribution to Lack of Follow-Through. ANKK1 and 5HTTLPR (both in interaction with early adversity) made independent contributions to Feelings Trigger Action. Thus, five polymorphisms contributed to predicting impulsivity, but different polymorphisms related to different aspects.
KW - 5HTTLPR
KW - ANKK1
KW - BDNF
KW - COMT
KW - DRD4
KW - impulsiveness
UR - http://www.scopus.com/inward/record.url?scp=84903517969&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84903517969&partnerID=8YFLogxK
U2 - 10.1177/1948550614527116
DO - 10.1177/1948550614527116
M3 - Article
AN - SCOPUS:84903517969
VL - 5
SP - 730
EP - 739
JO - Social Psychological and Personality Science
JF - Social Psychological and Personality Science
SN - 1948-5506
IS - 6
ER -