Gene Effects and G × E Interactions in the Differential Prediction of Three Aspects of Impulsiveness

Charles S. Carver, Joelle LeMoult, Sheri L. Johnson, Jutta Joormann

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Several polymorphisms relevant to dopamine and serotonin have been identified as potential contributors to individual differences in impulsivity versus self-control. Because impulsivity is a multifaceted construct, a need remains to examine more closely how various genes relate to different aspects of impulsivity. We examined four dopamine-related polymorphisms and the serotonin transporter as predictors of three aspects of impulsivity, two bearing on impulsive reactions to emotions and one on difficulty in completing intended actions. Early adversity was also examined as a potentiator of genetic effects. Undergraduates completed measures of impulsivity and early adversity and were genotyped. COMT, BDNF, DRD4, and 5HTTLPR (the latter two in interaction with early adversity) made independent contributions to prediction of Pervasive Influence of Feelings. BDNF made a contribution to Lack of Follow-Through. ANKK1 and 5HTTLPR (both in interaction with early adversity) made independent contributions to Feelings Trigger Action. Thus, five polymorphisms contributed to predicting impulsivity, but different polymorphisms related to different aspects.

Original languageEnglish (US)
Pages (from-to)730-739
Number of pages10
JournalSocial Psychological and Personality Science
Volume5
Issue number6
DOIs
StatePublished - Aug 2014

Keywords

  • 5HTTLPR
  • ANKK1
  • BDNF
  • COMT
  • DRD4
  • impulsiveness

ASJC Scopus subject areas

  • Social Psychology
  • Clinical Psychology

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