Abstract
The apolipoprotein E type 4 allele (APOE-∈4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-∈4 alleles in 42 families with late onset AD. Thus APOE-∈4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-∈4 was virtually sufficient to cause AD by age 80.
Original language | English (US) |
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Pages (from-to) | 921-923 |
Number of pages | 3 |
Journal | Science |
Volume | 261 |
Issue number | 5123 |
DOIs | |
State | Published - Jan 1 1993 |
Externally published | Yes |
ASJC Scopus subject areas
- General