Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

E. H. Corder; A. M. Saunders; W. J. Strittmatter; D. E. Schmechel; P. C. Gaskell; G. W. Small; A. D. Roses; J. L. Haines; M. A. Pericak-Vance

doi:10.1126/science.8346443

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

E. H. Corder, A. M. Saunders, W. J. Strittmatter, D. E. Schmechel, P. C. Gaskell, G. W. Small, A. D. Roses, J. L. Haines, M. A. Pericak-Vance

Research output: Contribution to journal › Article › peer-review

6505 Scopus citations

Abstract

The apolipoprotein E type 4 allele (APOE-∈4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-∈4 alleles in 42 families with late onset AD. Thus APOE-∈4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-∈4 was virtually sufficient to cause AD by age 80.

Original language	English (US)
Pages (from-to)	921-923
Number of pages	3
Journal	Science
Volume	261
Issue number	5123
DOIs	https://doi.org/10.1126/science.8346443
State	Published - Jan 1 1993
Externally published	Yes

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. / Corder, E. H.; Saunders, A. M.; Strittmatter, W. J.; Schmechel, D. E.; Gaskell, P. C.; Small, G. W.; Roses, A. D.; Haines, J. L.; Pericak-Vance, M. A.

In: Science, Vol. 261, No. 5123, 01.01.1993, p. 921-923.

Research output: Contribution to journal › Article › peer-review

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abstract = "The apolipoprotein E type 4 allele (APOE-∈4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-∈4 alleles in 42 families with late onset AD. Thus APOE-∈4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-∈4 was virtually sufficient to cause AD by age 80.",

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