Abstract
The apolipoprotein E type 4 allele (APOE-∈4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-∈4 alleles in 42 families with late onset AD. Thus APOE-∈4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-∈4 was virtually sufficient to cause AD by age 80.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 921-923 |
| Number of pages | 3 |
| Journal | Science |
| Volume | 261 |
| Issue number | 5123 |
| DOIs | |
| State | Published - Jan 1 1993 |
| Externally published | Yes |
ASJC Scopus subject areas
- General
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Cite this
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993). Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science, 261(5123), 921-923. https://doi.org/10.1126/science.8346443