Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

E. H. Corder, A. M. Saunders, W. J. Strittmatter, D. E. Schmechel, P. C. Gaskell, G. W. Small, A. D. Roses, J. L. Haines, M. A. Pericak-Vance

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Abstract

The apolipoprotein E type 4 allele (APOE-∈4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-∈4 alleles in 42 families with late onset AD. Thus APOE-∈4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-∈4 was virtually sufficient to cause AD by age 80.

Original languageEnglish (US)
Pages (from-to)921-923
Number of pages3
JournalScience
Volume261
Issue number5123
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

ASJC Scopus subject areas

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    Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993). Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science, 261(5123), 921-923. https://doi.org/10.1126/science.8346443