@article{224e4c07072a4ccc988ab4f56167450c,
title = "GDNF neurotrophic factor signalling determines the fate of dermal fibroblasts in wound-induced hair neogenesis and skin regeneration",
abstract = "We propose that GDNF, a glial cell line-derived neurotrophic factor, can promote hair follicle neogenesis and skin regeneration after wounding by directing the fate of dermal fibroblasts. Our hypothesis is largely based on detailed GDNF and receptor analysis during skin regenerative stages, as well as the induction of GDNF receptors after wounding between the pro-regenerative spiny mouse (genus Acomys) and its less-regenerative descendant, the house mouse (Mus musculus). To characterize the GDNF-target cells, we will conduct a series of lineage-tracing experiments in conjunction with single-cell RNA and assay for transposase-accessible chromatin sequencing experiments. The heterogenetic dynamics of skin regeneration have yet to be fully defined, and this research will help to advance the fields of regenerative medicine and biology. Finally, we believe that stimulating the GDNF signalling pathway in fibroblasts from less-regenerative animals, such as humans, will promote skin regeneration, morphogenesis and scarless wound healing.",
keywords = "GDNF, GFRA1, RET, fibroblasts, hair follicles, regeneration, skin, stem cells, wound healing, wound repair",
author = "Neda Vishlaghi and Sandra Rieger and Vanessa McGaughey and Lisse, {Thomas S.}",
note = "Funding Information: We would like to thank Dr. Hilmar Vidarsson and Dr. Bj{\"o}rn {\"O}rvar (ORF Genetics Inc., Iceland) for providing the GDNF compound. TSL is supported by Grant # IRG‐17‐183‐16 from the American Cancer Society, and from the Sylvester Comprehensive Cancer Center at the Miller School of Medicine, and College of Arts and Sciences, University of Miami. NV is supported by a Bridge Funding Fellowship provided by the College of Arts and Sciences, University of Miami. SR is supported by NCI/NIH 1R01CA215973‐01. Funding Information: We would like to thank Dr. Hilmar Vidarsson and Dr. Bj?rn ?rvar (ORF Genetics Inc., Iceland) for providing the GDNF compound. TSL is supported by Grant # IRG-17-183-16 from the American Cancer Society, and from the Sylvester Comprehensive Cancer Center at the Miller School of Medicine, and College of Arts and Sciences, University of Miami. NV is supported by a Bridge Funding Fellowship provided by the College of Arts and Sciences, University of Miami. SR is supported by NCI/NIH 1R01CA215973-01. Publisher Copyright: {\textcopyright} 2022 The Authors. Experimental Dermatology published by John Wiley & Sons Ltd.",
year = "2022",
month = apr,
doi = "10.1111/exd.14526",
language = "English (US)",
volume = "31",
pages = "577--581",
journal = "Experimental Dermatology",
issn = "0906-6705",
publisher = "Wiley-Blackwell",
number = "4",
}