GAVA: Spectral simulation for in vivo MRS applications

Brian J. Soher; Karl Young; Aaron Bernstein; Zakaria Aygula; Andrew A. Maudsley

doi:10.1016/j.jmr.2007.01.005

GAVA: Spectral simulation for in vivo MRS applications

Brian J. Soher, Karl Young, Aaron Bernstein, Zakaria Aygula, Andrew A. Maudsley

Radiology

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

An application that provides a flexible and easy to use interface to the GAMMA spectral simulation package is described that is targeted at investigations using in vivo MR spectroscopic methods. The program makes available a number of widely used spatially localized MRS pulse sequences and NMR parameters for commonly observed tissue metabolites, enabling spectra to be simulated for any pulse sequence parameter and viewed in an integrated display. The application is interfaced with a database for storage of all simulation parameters and results of the simulations. This application provides a convenient method for generating a priori spectral information used in parametric spectral analyses and for visual examination of the effects of difference pulse sequences and parameter settings.

Original language	English (US)
Pages (from-to)	291-299
Number of pages	9
Journal	Journal of Magnetic Resonance
Volume	185
Issue number	2
DOIs	https://doi.org/10.1016/j.jmr.2007.01.005
State	Published - Apr 2007

Keywords

GAMMA
MR spectroscopy
Parametric spectral analysis
Software
Spectral simulation

ASJC Scopus subject areas

Molecular Biology
Physical and Theoretical Chemistry
Spectroscopy
Radiology Nuclear Medicine and imaging
Condensed Matter Physics

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10.1016/j.jmr.2007.01.005

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title = "GAVA: Spectral simulation for in vivo MRS applications",

abstract = "An application that provides a flexible and easy to use interface to the GAMMA spectral simulation package is described that is targeted at investigations using in vivo MR spectroscopic methods. The program makes available a number of widely used spatially localized MRS pulse sequences and NMR parameters for commonly observed tissue metabolites, enabling spectra to be simulated for any pulse sequence parameter and viewed in an integrated display. The application is interfaced with a database for storage of all simulation parameters and results of the simulations. This application provides a convenient method for generating a priori spectral information used in parametric spectral analyses and for visual examination of the effects of difference pulse sequences and parameter settings.",

keywords = "GAMMA, MR spectroscopy, Parametric spectral analysis, Software, Spectral simulation",

author = "Soher, {Brian J.} and Karl Young and Aaron Bernstein and Zakaria Aygula and Maudsley, {Andrew A.}",

note = "Funding Information: The authors thank Dr. Govindaraju Varanavasi for his extensive beta testing of the development code. This work was supported by PHS Grants R01EB00207 and R01EB000822.",

year = "2007",

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doi = "10.1016/j.jmr.2007.01.005",

language = "English (US)",

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AU - Soher, Brian J.

AU - Young, Karl

AU - Bernstein, Aaron

AU - Aygula, Zakaria

AU - Maudsley, Andrew A.

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