Gating currents in the node of Ranvier: voltage and time dependence.

W. Nonner, E. Rojas, R. Stämpfli

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Like the axolemma of the giant nerve fibre of the squid, the nodal membrane of frog myelinated nerve fibres after blocking transmembrane ionic currents exhibits asymmetrical displacement currents during and after hyperpolarizing and depolarizing voltage clamp pulses of equal size. The steady-state distribution of charges as a function of membrane potential is consistent with Boltzmanns law (midpoint potential minus 33.7 mV; saturation value 17200 charges/mum-2). The time course of the asymmetry current and the voltage dependence of its time constant are consistent with the notion that due to a sudden change in membrane potential the charges undergo a first order transition between two configurations. Size and voltage dependence of the time constant are similar to those of the activation of the sodium conductance assuming m-2h kinetics. The results suggest that the presence of ten times more sodium channels (5000/mum-2) in the node of Ranvier than in the squid giant axon with similar sodium conductance per channel (2-3 pS).

Original languageEnglish (US)
Pages (from-to)483-492
Number of pages10
JournalPhilosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume270
Issue number908
DOIs
StatePublished - Jun 10 1975

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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