Gastroretentive: A controlled release drug delivery system

Sonia Dhiman, Thakur Gurjeet Singh, Ashish Kumar Rehni, Surbhi Sood, Sandeep Arora

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

There has been a lot of trouble in absorption of drugs having narrow absorption window. Major physiological adversities to overcome include short residence time (GRT) and unpredictable gastric empting time (GET). According to previous studies it has been seen that differences in gastric physiology, such as gastric pH, and motility exhibit both intra as well as inter subject variability demonstrating significant impact on gastric retention time and drug delivery behavior. Various approaches are currently being used in the prolongation of the GRT including floating drug delivery systems (FDDS), swelling and expanding systems, polymeric bioadhesive systems, high density systems, modified shape systems and other delayed gastric empting devices. This review article focuses on the current technological development in FDDS with special emphasis on the principal mechanism of floatation and advantages to achieve gastric retention and its potential for oral controlled drug delivery.

Original languageEnglish (US)
Pages (from-to)5-13
Number of pages9
JournalAsian Journal of Pharmaceutical and Clinical Research
Volume4
Issue numberSUPPL. 1
StatePublished - Sep 2011
Externally publishedYes

Keywords

  • Floating drug delivery systems
  • Gastric empting time
  • Short residence time

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

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