Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection

Ronald S. Veazey; Mary Ann DeMaria; Laura V. Chalifoux; Daniel E. Shvetz; Douglas R. Pauley; Heather L. Knight; Michael Rosenzweig; R. Paul Johnson; Ronald C. Desrosiers; Andrew A. Lackner

doi:10.1126/science.280.5362.427

Gastrointestinal tract as a major site of CD4⁺ T cell depletion and viral replication in SIV infection

Ronald S. Veazey, Mary Ann DeMaria, Laura V. Chalifoux, Daniel E. Shvetz, Douglas R. Pauley, Heather L. Knight, Michael Rosenzweig, R. Paul Johnson, Ronald C. Desrosiers, Andrew A. Lackner

Research output: Contribution to journal › Article › peer-review

1131 Scopus citations

Abstract

Human and simian immunodeficiency virus (HIV and SIV) replicate optimally in activated memory CD⁴ T cells, a cell type that is abundant in the intestine. SIV infection of rhesus monkeys resulted in profound and selective depletion of CD⁴ T cells in the intestine within days of infection, before any such changes in peripheral lymphoid tissues. The loss of CD⁴ T cells in the intestine occurred coincident with productive infection of large numbers of mononuclear cells at this site. The intestine appears to be a major target for SIV replication and the major site of CD⁺ T cell loss in early SIV infection.

Original language	English (US)
Pages (from-to)	427-431
Number of pages	5
Journal	Science
Volume	280
Issue number	5362
DOIs	https://doi.org/10.1126/science.280.5362.427
State	Published - Apr 17 1998
Externally published	Yes

ASJC Scopus subject areas

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Gastrointestinal tract as a major site of CD4⁺ T cell depletion and viral replication in SIV infection. / Veazey, Ronald S.; DeMaria, Mary Ann; Chalifoux, Laura V.; Shvetz, Daniel E.; Pauley, Douglas R.; Knight, Heather L.; Rosenzweig, Michael; Johnson, R. Paul; Desrosiers, Ronald C.; Lackner, Andrew A.

In: Science, Vol. 280, No. 5362, 17.04.1998, p. 427-431.

Research output: Contribution to journal › Article › peer-review

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abstract = "Human and simian immunodeficiency virus (HIV and SIV) replicate optimally in activated memory CD4 T cells, a cell type that is abundant in the intestine. SIV infection of rhesus monkeys resulted in profound and selective depletion of CD4 T cells in the intestine within days of infection, before any such changes in peripheral lymphoid tissues. The loss of CD4 T cells in the intestine occurred coincident with productive infection of large numbers of mononuclear cells at this site. The intestine appears to be a major target for SIV replication and the major site of CD+ T cell loss in early SIV infection.",

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