Abstract
Human and simian immunodeficiency virus (HIV and SIV) replicate optimally in activated memory CD4 T cells, a cell type that is abundant in the intestine. SIV infection of rhesus monkeys resulted in profound and selective depletion of CD4 T cells in the intestine within days of infection, before any such changes in peripheral lymphoid tissues. The loss of CD4 T cells in the intestine occurred coincident with productive infection of large numbers of mononuclear cells at this site. The intestine appears to be a major target for SIV replication and the major site of CD+ T cell loss in early SIV infection.
Original language | English (US) |
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Pages (from-to) | 427-431 |
Number of pages | 5 |
Journal | Science |
Volume | 280 |
Issue number | 5362 |
DOIs | |
State | Published - Apr 17 1998 |
Externally published | Yes |
ASJC Scopus subject areas
- General