Gastrointestinal stromal tumor and its targeted therapeutics

Jheri Dupart, Wei Zhang, Jonathan C. Trent

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Over the past 60 years, investigators of basic science, pathology, and clinical medicine have studied gastrointestinal stromal tumor (GIST) and made minor advances in patient care. Recent discoveries have led to an understanding of the biological role of KIT and platelet-derived growth factor receptor-α in GIST and the development of the tyrosine kinase inhibitor imatinib mesylate (Gleevec, formerly STI-57 1), one of the most exciting examples of targeted therapy to date. The success of targeted therapy in GIST has lead to new developments in our understanding of the medical and surgical management of the disease. Intense study of GIST may lead to new paradigms in the management of cancer.

Original languageEnglish (US)
Pages (from-to)303-314
Number of pages12
JournalChinese journal of cancer
Volume30
Issue number5
DOIs
StatePublished - 2011

Keywords

  • Gastrointestinal stromal tumor
  • Imatinib mesylate
  • KIT
  • Platelet-derived growth factor receptor

ASJC Scopus subject areas

  • Oncology

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