Gastrointestinal secretory, motor, circulatory, and metabolic effects of prosomatostatin

S. J. Konturek, J. Tasler, J. Jaworek, W. Pawlik, K. M. Walus, V. Schusdziarra, C. A. Meyers, D. H. Coy, A. V. Schally

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39 Scopus citations

Abstract

This study compares the gastrointestinal effects of somatostatin (SS) and its putative prohormone, prosomatostatin (Pro-SS), a 28-amino acid peptide isolated from the hypothalamus and the gut, in conscious dogs with chronic gastric and pancreatic fistulae. Pro-SS suppressed the release of serum gastrin, insulin, and pancreatic polypeptide that occurs in response to feeding a meat meal in a manner similar to that seen with SS. However, in contrast to SS, which strongly reduced intestinal blood flow and oxygen consumption and stimulated intestinal motility, Pro-SS, at the doses tested, had no influence on mesenteric circulation oxygen uptake, and intestinal motility. We conclude that Pro-SS mimicks most of the gastrointestinal secretory actions of SS, but does not exhibit the intestinal circulatory, metabolic, and motor effects of SS.

Original languageEnglish (US)
Pages (from-to)1967-1971
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume78
Issue number3 I
DOIs
StatePublished - 1981

ASJC Scopus subject areas

  • General

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