Gastrointestinal secretory, motor, circulatory, and metabolic effects of prosomatostatin

S. J. Konturek, J. Tasler, J. Jaworek, W. Pawlik, K. M. Walus, V. Schusdziarra, C. A. Meyers, D. H. Coy, Andrew V Schally

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

This study compares the gastrointestinal effects of somatostatin (SS) and its putative prohormone, prosomatostatin (Pro-SS), a 28-amino acid peptide isolated from the hypothalamus and the gut, in conscious dogs with chronic gastric and pancreatic fistulae. Pro-SS suppressed the release of serum gastrin, insulin, and pancreatic polypeptide that occurs in response to feeding a meat meal in a manner similar to that seen with SS. However, in contrast to SS, which strongly reduced intestinal blood flow and oxygen consumption and stimulated intestinal motility, Pro-SS, at the doses tested, had no influence on mesenteric circulation oxygen uptake, and intestinal motility. We conclude that Pro-SS mimicks most of the gastrointestinal secretory actions of SS, but does not exhibit the intestinal circulatory, metabolic, and motor effects of SS.

Original languageEnglish
Pages (from-to)1967-1971
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume78
Issue number3 I
DOIs
StatePublished - Dec 6 1981
Externally publishedYes

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Somatostatin
Gastrointestinal Motility
Splanchnic Circulation
Gastric Fistula
Pancreatic Fistula
Pancreatic Polypeptide
Gastrins
Oxygen Consumption
Meat
Hypothalamus
Meals
prosomatostatin
Dogs
Insulin
Oxygen
Amino Acids
Peptides
Serum

ASJC Scopus subject areas

  • Genetics
  • General

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Gastrointestinal secretory, motor, circulatory, and metabolic effects of prosomatostatin. / Konturek, S. J.; Tasler, J.; Jaworek, J.; Pawlik, W.; Walus, K. M.; Schusdziarra, V.; Meyers, C. A.; Coy, D. H.; Schally, Andrew V.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 78, No. 3 I, 06.12.1981, p. 1967-1971.

Research output: Contribution to journalArticle

Konturek, S. J. ; Tasler, J. ; Jaworek, J. ; Pawlik, W. ; Walus, K. M. ; Schusdziarra, V. ; Meyers, C. A. ; Coy, D. H. ; Schally, Andrew V. / Gastrointestinal secretory, motor, circulatory, and metabolic effects of prosomatostatin. In: Proceedings of the National Academy of Sciences of the United States of America. 1981 ; Vol. 78, No. 3 I. pp. 1967-1971.
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