Gastrointestinal secretory, motor and circulatory effects of corticotropin releasing factor (CRF)

S. J. Konturek, J. Bilski, W. Pawlik, P. Thor, K. Czarnobilski, B. Szoke, A. V. Schally

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

This study was designed to determined the effects of CRF on the gastrointestinal functions such as secretion, motility and circulation in dogs. CRF was found to inhibit dose-dependently gastric acid response to pentagastrin but not to histamine. CRF stimulated pancreatic bicarbonate and protein secretion under basal conditions and in response to secretin or cholecystokinin (CCK). This stimulation was accompanied by an increase in plasma levels of pancreatic polypeptide (PP), but not of secretin or gastrin. CRF caused a partial inhibition of the migrating motor complexes in fasted dogs and increased spike activity of the small bowel. These motor effects of CRF probably resulted from the action of the released PP on the intestinal smooth muscle. CRF is also a potent and selective stimulant of the mesenteric blood flow. This effect may be secondary to the stimulation of intestinal motility and metabolism.

Original languageEnglish (US)
Pages (from-to)1231-1240
Number of pages10
JournalLife Sciences
Volume37
Issue number13
DOIs
StatePublished - Sep 30 1985
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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