Gastrointestinal malignancy and the microbiome

Maria T. Abreu, Richard M. Peek

Research output: Contribution to journalArticle

144 Scopus citations

Abstract

Microbial species participate in the genesis of a substantial number of malignancies - in conservative estimates, at least 15% of all cancer cases are attributable to infectious agents. Little is known about the contribution of the gastrointestinal microbiome to the development of malignancies. Resident microbes can promote carcinogenesis by inducing inflammation, increasing cell proliferation, altering stem cell dynamics, and producing metabolites such as butyrate, which affect DNA integrity and immune regulation. Studies in human beings and rodent models of cancer have identified effector species and relationships among members of the microbial community in the stomach and colon that increase the risk for malignancy. Strategies to manipulate the microbiome, or the immune response to such bacteria, could be developed to prevent or treat certain gastrointestinal cancers.

Original languageEnglish (US)
Pages (from-to)1534-1546.e3
JournalGastroenterology
Volume146
Issue number6
DOIs
StatePublished - May 2014

Keywords

  • Bacteria
  • Cancer
  • Inflammation

ASJC Scopus subject areas

  • Gastroenterology

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