Gastrointestinal malignancy and the microbiome

Maria T Abreu, Richard M. Peek

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

Microbial species participate in the genesis of a substantial number of malignancies - in conservative estimates, at least 15% of all cancer cases are attributable to infectious agents. Little is known about the contribution of the gastrointestinal microbiome to the development of malignancies. Resident microbes can promote carcinogenesis by inducing inflammation, increasing cell proliferation, altering stem cell dynamics, and producing metabolites such as butyrate, which affect DNA integrity and immune regulation. Studies in human beings and rodent models of cancer have identified effector species and relationships among members of the microbial community in the stomach and colon that increase the risk for malignancy. Strategies to manipulate the microbiome, or the immune response to such bacteria, could be developed to prevent or treat certain gastrointestinal cancers.

Original languageEnglish
JournalGastroenterology
Volume146
Issue number6
DOIs
StatePublished - Jan 1 2014

Fingerprint

Neoplasms
Gastrointestinal Neoplasms
Butyrates
Microbiota
Rodentia
Stomach
Colon
Carcinogenesis
Stem Cells
Cell Proliferation
Gastrointestinal Microbiome
Inflammation
Bacteria
DNA

Keywords

  • Bacteria
  • Cancer
  • Inflammation

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Gastrointestinal malignancy and the microbiome. / Abreu, Maria T; Peek, Richard M.

In: Gastroenterology, Vol. 146, No. 6, 01.01.2014.

Research output: Contribution to journalArticle

Abreu, Maria T ; Peek, Richard M. / Gastrointestinal malignancy and the microbiome. In: Gastroenterology. 2014 ; Vol. 146, No. 6.
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