Gastric retention of enteric-coated sulfasalazine tablets - A complication of gastroduodenal Crohn's disease

Albert M. Harary; Charles A. Gluck; Arvey I. Rogers

doi:10.1007/BF01311262

Gastric retention of enteric-coated sulfasalazine tablets - A complication of gastroduodenal Crohn's disease

Albert M. Harary, Charles A. Gluck, Arvey I. Rogers

Medicine

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2 Scopus citations

Abstract

A case is described in which a patient with known gastroduodenal Crohn's disease developed a picture of gastric outlet obstruction accompained by gastric retention of many enteric-coated sulfasalazine tablets. The tablets were removed by gastric lavage with a sodium bicarbonate solution. Following this observation, an in vitro study was done in which the rate of disintegration of enteric-coated sulfasalazine tablets was found to be directly related to pH. The case report reveals a potential hazard in using enteric-coated tablets in patients with impaired gastric emptying. Intragastric sodium bicarbonate may be a useful element in the management of this complication.

Original language	English (US)
Pages (from-to)	1063-1065
Number of pages	3
Journal	Digestive Diseases and Sciences
Volume	29
Issue number	11
DOIs	https://doi.org/10.1007/BF01311262
State	Published - Nov 1 1984

ASJC Scopus subject areas

Physiology
Gastroenterology

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abstract = "A case is described in which a patient with known gastroduodenal Crohn's disease developed a picture of gastric outlet obstruction accompained by gastric retention of many enteric-coated sulfasalazine tablets. The tablets were removed by gastric lavage with a sodium bicarbonate solution. Following this observation, an in vitro study was done in which the rate of disintegration of enteric-coated sulfasalazine tablets was found to be directly related to pH. The case report reveals a potential hazard in using enteric-coated tablets in patients with impaired gastric emptying. Intragastric sodium bicarbonate may be a useful element in the management of this complication.",

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AU - Gluck, Charles A.

AU - Rogers, Arvey I.

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N2 - A case is described in which a patient with known gastroduodenal Crohn's disease developed a picture of gastric outlet obstruction accompained by gastric retention of many enteric-coated sulfasalazine tablets. The tablets were removed by gastric lavage with a sodium bicarbonate solution. Following this observation, an in vitro study was done in which the rate of disintegration of enteric-coated sulfasalazine tablets was found to be directly related to pH. The case report reveals a potential hazard in using enteric-coated tablets in patients with impaired gastric emptying. Intragastric sodium bicarbonate may be a useful element in the management of this complication.

AB - A case is described in which a patient with known gastroduodenal Crohn's disease developed a picture of gastric outlet obstruction accompained by gastric retention of many enteric-coated sulfasalazine tablets. The tablets were removed by gastric lavage with a sodium bicarbonate solution. Following this observation, an in vitro study was done in which the rate of disintegration of enteric-coated sulfasalazine tablets was found to be directly related to pH. The case report reveals a potential hazard in using enteric-coated tablets in patients with impaired gastric emptying. Intragastric sodium bicarbonate may be a useful element in the management of this complication.

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Gastric retention of enteric-coated sulfasalazine tablets - A complication of gastroduodenal Crohn's disease

Abstract

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