Abstract
A case is described in which a patient with known gastroduodenal Crohn's disease developed a picture of gastric outlet obstruction accompained by gastric retention of many enteric-coated sulfasalazine tablets. The tablets were removed by gastric lavage with a sodium bicarbonate solution. Following this observation, an in vitro study was done in which the rate of disintegration of enteric-coated sulfasalazine tablets was found to be directly related to pH. The case report reveals a potential hazard in using enteric-coated tablets in patients with impaired gastric emptying. Intragastric sodium bicarbonate may be a useful element in the management of this complication.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1063-1065 |
| Number of pages | 3 |
| Journal | Digestive Diseases and Sciences |
| Volume | 29 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1 1984 |
ASJC Scopus subject areas
- Physiology
- Gastroenterology
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Harary, A. M., Gluck, C. A., & Rogers, A. I. (1984). Gastric retention of enteric-coated sulfasalazine tablets - A complication of gastroduodenal Crohn's disease. Digestive Diseases and Sciences, 29(11), 1063-1065. https://doi.org/10.1007/BF01311262