Abstract
A case is described in which a patient with known gastroduodenal Crohn's disease developed a picture of gastric outlet obstruction accompained by gastric retention of many enteric-coated sulfasalazine tablets. The tablets were removed by gastric lavage with a sodium bicarbonate solution. Following this observation, an in vitro study was done in which the rate of disintegration of enteric-coated sulfasalazine tablets was found to be directly related to pH. The case report reveals a potential hazard in using enteric-coated tablets in patients with impaired gastric emptying. Intragastric sodium bicarbonate may be a useful element in the management of this complication.
Original language | English (US) |
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Pages (from-to) | 1063-1065 |
Number of pages | 3 |
Journal | Digestive Diseases and Sciences |
Volume | 29 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1 1984 |
ASJC Scopus subject areas
- Physiology
- Gastroenterology