Gastric retention of enteric-coated sulfasalazine tablets - A complication of gastroduodenal Crohn's disease

Albert M. Harary, Charles A. Gluck, Arvey I. Rogers

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

A case is described in which a patient with known gastroduodenal Crohn's disease developed a picture of gastric outlet obstruction accompained by gastric retention of many enteric-coated sulfasalazine tablets. The tablets were removed by gastric lavage with a sodium bicarbonate solution. Following this observation, an in vitro study was done in which the rate of disintegration of enteric-coated sulfasalazine tablets was found to be directly related to pH. The case report reveals a potential hazard in using enteric-coated tablets in patients with impaired gastric emptying. Intragastric sodium bicarbonate may be a useful element in the management of this complication.

Original languageEnglish (US)
Pages (from-to)1063-1065
Number of pages3
JournalDigestive Diseases and Sciences
Volume29
Issue number11
DOIs
StatePublished - Nov 1 1984

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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