Gastric endocrine pancreatic heterotopia: Report of a case with histologic and immunohistochemical findings and review of the literature

Lauren Hammock, Merce Jorda

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Heterotopic pancreas is a relatively infrequent lesion most often found in the stomach. Four histologic types are recognized: total, canalicular, exocrine, and endocrine heterotopia. To our knowledge, only 2 cases of purely endocrine heterotopic pancreas have been reported in detail. We describe the case of a patient with gastric and duodenal ulcers and gastric endocrine heterotopia. The lack of mass formation, histomorphology, and immunohistochemical features simulating islets of Langerhans supported the diagnosis. We conclude that purely endocrine heterotopic pancreas is a very rare entity that, when present, can simulate a primary or metastatic neuroendocrine tumor. Adequate sampling of the specimen, histomorphologic pattern, and immunohistochemistry are important for the purpose of distinguishing between a neuroendocrine tumor and purely endocrine pancreatic heterotopia.

Original languageEnglish (US)
Pages (from-to)464-467
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume126
Issue number4
StatePublished - Apr 17 2002

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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