Gastric cancer, version 2.2013

Jaffer A. Ajani, David J. Bentrem, Stephen Besh, Thomas A. D'Amico, Prajnan Das, Crystal Denlinger, Marwan G. Fakih, Charles S. Fuchs, Hans Gerdes, Robert E. Glasgow, James A. Hayman, Wayne L. Hofstetter, David H. Ilson, Rajesh N. Keswani, Lawrence R. Kleinberg, W. Michael Korn, A. Craig Lockhart, Kenneth Meredith, Mary F. Mulcahy, Mark B. OrringerJames A. Posey, Aaron R. Sasson, Walter J. Scott, Vivian E. Strong, Thomas K. Varghese, Graham Warren, Mary Kay Washington, Christopher Willett, Cameron D. Wright, Nicole R. McMillian, Hema Sundar

Research output: Contribution to journalArticle

312 Scopus citations

Abstract

The NCCN Clinical Practice Guidelines in Oncology for Gastric Cancer provide evidence- and consensus-based recommendations for a multidisciplinary approach for the management of patients with gastric cancer. For patients with resectable locoregional cancer, the guidelines recommend gastrectomy with a D1+ or a modified D2 lymph node dissection (performed by experienced surgeons in high-volume centers). Postoperative chemoradiation is the preferred option after complete gastric resection for patients with T3-T4 tumors and node-positive T1-T2 tumors. Postoperative chemotherapy is included as an option after a modified D2 lymph node dissection for this group of patients. Trastuzumab with chemotherapy is recommended as first-line therapy for patients with HER2-positive advanced or metastatic cancer, confirmed by immunohistochemistry and, if needed, by fluorescence in situ hybridization for IHC 2+.

Original languageEnglish (US)
Pages (from-to)531-546
Number of pages16
JournalJNCCN Journal of the National Comprehensive Cancer Network
Volume11
Issue number5
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Oncology

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    Ajani, J. A., Bentrem, D. J., Besh, S., D'Amico, T. A., Das, P., Denlinger, C., Fakih, M. G., Fuchs, C. S., Gerdes, H., Glasgow, R. E., Hayman, J. A., Hofstetter, W. L., Ilson, D. H., Keswani, R. N., Kleinberg, L. R., Korn, W. M., Lockhart, A. C., Meredith, K., Mulcahy, M. F., ... Sundar, H. (2013). Gastric cancer, version 2.2013. JNCCN Journal of the National Comprehensive Cancer Network, 11(5), 531-546. https://doi.org/10.6004/jnccn.2013.0070