Gap junction modulation and its implications for heart function

Stefan Kurtenbach, Sarah Kurtenbach, Georg Zoidl

Research output: Contribution to journalShort surveypeer-review

37 Scopus citations

Abstract

Gap junction communication (GJC) mediated by connexins is critical for heart function. To gain insight into the causal relationship of molecular mechanisms of disease pathology, it is important to understand which mechanisms contribute to impairment of gap junctional communication. Here, we present an update on the known modulators of connexins, including various interaction partners, kinases, and signaling cascades. This gap junction network (GJN) can serve as a blueprint for data mining approaches exploring the growing number of publicly available data sets from experimental and clinical studies.

Original languageEnglish (US)
Article numberArticle 82
JournalFrontiers in Physiology
Volume5 FEB
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Connexin
  • Gap junction communication
  • Heart
  • Interactome
  • Signaling pathway

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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