Gamma knife radiosurgery for large volume brain tumors: An analysis of acute and chronic toxicity

D. Linzer, S. M. Ling, H. Villalobos, W. Raub, X. Wu, J. Ting, A. Berti, H. Landy, A. M. Markoe

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Gamma Knife radiosurgery is often used to treat intracranial tumors <4 cm (approximately 13.5 cm3) in mean diameter. Larger lesions are rarely treated because of the expectation that increasing target volume will increase toxicity. We retrospectively analyzed 35 patients with primary or metastatic brain tumors of more than 13.5 cm3 treated with the Gamma Knife. Only 3 (8.5%) patients developed acute clinical toxicity. Nine (25%) patients developed post-Gamma Knife radionecrosis based on imaging studies, with only 3 of these patients (9% of the study population) having clinical progression of symptoms. Necrosis was not found to be related to prescribed dose, treatment volume or number of treated isocenters. We found no undue toxicity from the treatment of large brain tumors with the Gamma Knife.

Original languageEnglish (US)
Pages (from-to)11-18
Number of pages8
JournalStereotactic and Functional Neurosurgery
Volume70
Issue numberSUPPL. 1
DOIs
StatePublished - Nov 2 1998

Keywords

  • Brain tumor
  • Gamma Knife
  • Metastasis
  • Stereotactic radiosurgery
  • Toxicity
  • Volume

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Gamma knife radiosurgery for large volume brain tumors: An analysis of acute and chronic toxicity'. Together they form a unique fingerprint.

  • Cite this