Galanin: neuromodulatory and direct contractile effects on smooth muscle preparations

E. Ekblad, R. Håkanson, F. Sundler, C. Wahlestedt

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Abstract

1. The effects of galanin, a newly isolated neuropeptide, and of a galanin fragment (galanin 1-10) were studied on various smooth muscle preparations in vitro. Direct motor effects as well as effects on electrically induced (neuronally mediated) responses (neuromodulatory effects) were observed. 2. Both gatanin and galanin 1-10 evoked a strong contractile response in rat jejunal longitudinal muscle. This effect was a direct one on the smooth muscle. 3. Addition of galanin to guinea-pig taenia coli inhibited the contractile responses to electrical stimulation, mediated by endogenous substance P and acetylcholine. In the rabbit iris sphincter, galanin reduced the acetylcholine-mediated but not the substance P-mediated contraction evoked by electrical stimulation. The neuromodulatory effects seem to be presynaptic and require the whole or possibly only the C-terminal part of the galanin molecule, since galanin 1-10 was ineffective. 4. Rabbit femoral artery and vein, gastroepiploic and basilar arteries and guinea-pig trachea and main bronchi did not respond to either galanin or galanin 1-10.

Original languageEnglish (US)
Pages (from-to)241-246
Number of pages6
JournalBritish Journal of Pharmacology
Volume86
Issue number1
DOIs
StatePublished - Sep 1985

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ASJC Scopus subject areas

  • Pharmacology

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