Gadolinium-DTPA-enhanced magnetic resonance imaging in optic neuropathies

John Guy, A. Mancuso, R. G. Quisling, R. Beck, M. Moster

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Magnetic resonance imaging (MRI), after intravenous administration of the paramagnetic agent gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA), showed enhancement of the optic nerve in 7 of 13 patients with acute optic neuritis. Four of these patients had Gd-DTPA enhancement of the intracranial optic nerve and two had involvement of the optic nerve at the orbital apex, ipsilateral to the eye with visual loss. Gadolinium-DTPA enhancement of both intracranial optic nerves was seen in one of two patients with bilateral retrobulbar neuritis. Two patients with acute radiation-induced optic neuropathy also had Gd-DTPA enhancement of the intracranial optic nerve. The authors recommend MRI with Gd-DTPA as the neuro-diagnostic procedure of choice for visualization of increased permeability of the blood-brain barrier in acute optic neuritis and radiation-induced optic neuropathy.

Original languageEnglish
Pages (from-to)592-600
Number of pages9
JournalOphthalmology
Volume97
Issue number5
StatePublished - May 28 1990
Externally publishedYes

Fingerprint

Optic Nerve Diseases
Gadolinium DTPA
Optic Nerve
Gadolinium
Optic Neuritis
Magnetic Resonance Imaging
Acids
Radiation
Blood-Brain Barrier
Intravenous Administration
Permeability

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Guy, J., Mancuso, A., Quisling, R. G., Beck, R., & Moster, M. (1990). Gadolinium-DTPA-enhanced magnetic resonance imaging in optic neuropathies. Ophthalmology, 97(5), 592-600.

Gadolinium-DTPA-enhanced magnetic resonance imaging in optic neuropathies. / Guy, John; Mancuso, A.; Quisling, R. G.; Beck, R.; Moster, M.

In: Ophthalmology, Vol. 97, No. 5, 28.05.1990, p. 592-600.

Research output: Contribution to journalArticle

Guy, J, Mancuso, A, Quisling, RG, Beck, R & Moster, M 1990, 'Gadolinium-DTPA-enhanced magnetic resonance imaging in optic neuropathies', Ophthalmology, vol. 97, no. 5, pp. 592-600.
Guy J, Mancuso A, Quisling RG, Beck R, Moster M. Gadolinium-DTPA-enhanced magnetic resonance imaging in optic neuropathies. Ophthalmology. 1990 May 28;97(5):592-600.
Guy, John ; Mancuso, A. ; Quisling, R. G. ; Beck, R. ; Moster, M. / Gadolinium-DTPA-enhanced magnetic resonance imaging in optic neuropathies. In: Ophthalmology. 1990 ; Vol. 97, No. 5. pp. 592-600.
@article{90ae9472303e482da60c3c5795f5861c,
title = "Gadolinium-DTPA-enhanced magnetic resonance imaging in optic neuropathies",
abstract = "Magnetic resonance imaging (MRI), after intravenous administration of the paramagnetic agent gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA), showed enhancement of the optic nerve in 7 of 13 patients with acute optic neuritis. Four of these patients had Gd-DTPA enhancement of the intracranial optic nerve and two had involvement of the optic nerve at the orbital apex, ipsilateral to the eye with visual loss. Gadolinium-DTPA enhancement of both intracranial optic nerves was seen in one of two patients with bilateral retrobulbar neuritis. Two patients with acute radiation-induced optic neuropathy also had Gd-DTPA enhancement of the intracranial optic nerve. The authors recommend MRI with Gd-DTPA as the neuro-diagnostic procedure of choice for visualization of increased permeability of the blood-brain barrier in acute optic neuritis and radiation-induced optic neuropathy.",
author = "John Guy and A. Mancuso and Quisling, {R. G.} and R. Beck and M. Moster",
year = "1990",
month = "5",
day = "28",
language = "English",
volume = "97",
pages = "592--600",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Gadolinium-DTPA-enhanced magnetic resonance imaging in optic neuropathies

AU - Guy, John

AU - Mancuso, A.

AU - Quisling, R. G.

AU - Beck, R.

AU - Moster, M.

PY - 1990/5/28

Y1 - 1990/5/28

N2 - Magnetic resonance imaging (MRI), after intravenous administration of the paramagnetic agent gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA), showed enhancement of the optic nerve in 7 of 13 patients with acute optic neuritis. Four of these patients had Gd-DTPA enhancement of the intracranial optic nerve and two had involvement of the optic nerve at the orbital apex, ipsilateral to the eye with visual loss. Gadolinium-DTPA enhancement of both intracranial optic nerves was seen in one of two patients with bilateral retrobulbar neuritis. Two patients with acute radiation-induced optic neuropathy also had Gd-DTPA enhancement of the intracranial optic nerve. The authors recommend MRI with Gd-DTPA as the neuro-diagnostic procedure of choice for visualization of increased permeability of the blood-brain barrier in acute optic neuritis and radiation-induced optic neuropathy.

AB - Magnetic resonance imaging (MRI), after intravenous administration of the paramagnetic agent gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA), showed enhancement of the optic nerve in 7 of 13 patients with acute optic neuritis. Four of these patients had Gd-DTPA enhancement of the intracranial optic nerve and two had involvement of the optic nerve at the orbital apex, ipsilateral to the eye with visual loss. Gadolinium-DTPA enhancement of both intracranial optic nerves was seen in one of two patients with bilateral retrobulbar neuritis. Two patients with acute radiation-induced optic neuropathy also had Gd-DTPA enhancement of the intracranial optic nerve. The authors recommend MRI with Gd-DTPA as the neuro-diagnostic procedure of choice for visualization of increased permeability of the blood-brain barrier in acute optic neuritis and radiation-induced optic neuropathy.

UR - http://www.scopus.com/inward/record.url?scp=0025267156&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025267156&partnerID=8YFLogxK

M3 - Article

C2 - 2342804

AN - SCOPUS:0025267156

VL - 97

SP - 592

EP - 600

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 5

ER -